胰腺癌基因治疗的研究现状

Gene therapy for pancreatic cancer

胰腺癌是消化道常见恶性肿瘤之一，早期诊断困难，手术切除率低，预后差，且发病率呈逐年上升趋势。胰腺癌的常规治疗方式包括手术治疗、放疗、化疗，但90％的患者在就诊时已失去手术机会，且胰腺癌对放疗、化疗均不敏感。相对于以上传统的治疗方式，基因治疗是一个充满活力的研究领域，近年来备受关注，其中很多研究已进入Ⅰ／Ⅱ临床试验阶段。胰腺癌基因治疗的研究主要包括：肿瘤裂解病毒治疗、反转录基因治疗、免疫基因治疗、自杀基因治疗。本文就近期胰腺癌的基因治疗研究成果与存在的问题作一综述。

Pancreatic cancer was one of common malignant tumors of the digestive tract, early diagnosis of which was difficult and surgical resection rate was low. The prognosis was poor, and its incidence increased year by year. Conventional treatment of pancreatic cancer includes surgery, radiotherapy and chemotherapy, but 90% of the patients had lost the surgical opportunity when they see a doctor, and not sensitive to radiotherapy and chemotherapy. Relative to these traditional treatments, gene therapy is an innovative approach for the treatment of pancreatic cancer and had attracted wide attention in recent years. Many gene therapy drugs for pancreatic cancer had now entered Ⅰ/Ⅱ clinical trials. The gene therapy techniques for pancreatic cancer included antisense gene therapy, suicide gene therapy, immune gene therapy, and oncolyric virus therapy. In this article, we reviewed recent advances in gene therapy for pancreatic cancer.