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转录因子FoxM1——癌症治疗新靶点 被引量：5

Transcription factor FoxM1-A novel target for cancer therapy
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摘要 转录因子FoxM1是Forkhead Box转录因子家族成员之一,与细胞增殖、胚胎发育、衰老、再生和肿瘤等许多病理生理过程密切相关。目前发现,在人类大多数肿瘤中FoxM1都具有较高的表达水平。并且,FoxM1与多种致瘤信号途径相关。FoxM1在细胞中的特殊功能以及与肿瘤的密切关系,使之成为肿瘤治疗的新靶点。 FoxM1 belongs to the Forkhead transcription factor family.FoxM1 plays important roles in the control of cellular proliferation,embryonic development,senescence,regeneration,and tumor progression.FoxM1 highly expresses in most of human tumors and is related to multiple oncogenic pathways.FoxM1 may be considered as a novel therapeutic target for cancer treatment due to its functions that correlate with tumors.
作者 余琪琪 孟蕾 谭拥军
机构地区 湖南大学生物学院
出处 《分子诊断与治疗杂志》 2011年第5期339-343,共5页 Journal of Molecular Diagnostics and Therapy
基金 国家自然科学基金(30871244)
关键词 FOXM1 转录因子 癌症治疗 FoxM1 Transcription factor Cancer therapy
分类号 R730.5 [医药卫生—肿瘤]
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参考文献12

  • 1Ledda-Columbano G M, Pibiri M, Cossu C, et al. Aging does not reduce the hepatocyte proliferative response of mice to the primary mitogen TCPOBOP[J]. Hepatology, 2004, 40(4): 981-988.
  • 2Kim I M, Ramakrishna S, Gusarova G A, et al. The forkhead box M1 transcription factor is essential for embryonic development of pulmonary vasculature[J]. J Biol Chem 2005,280(23):22278-22286.
  • 3Wang Z, Banerjee S, Kong D, et al. Down-regulation of forkhead box M1 transcription factor leads to the inhibition of invasion and angiogenesis of pancreatic cancer cells[J] Cancer Res, 2007, 67(17): 8293-8300.
  • 4Kalin T V, Wang I C, Ackerson T J, et al. Increased levels of the FoxM1 transcription factor accelerate development and progression of prostate carcinomas in both TRAMP and LADY transgenic mice[J]. Cancer Res, 2006, 66(3)1712-1720.
  • 5Kalinichenko V V, Major M L, Wang X, et al. FoxMlb transcription factor is essential for development of hepatocellular carcinomas and is negatively regulated by the pl9ARF tumor suppressor[J]. Genes Dev, 2004, 18(7) 830-850.
  • 6Liu M, Dai B, Kang S H, et al. FoxM1B is overexpressed in human glioblastomas and critically regulates the tumorigenicity of glioma cells[J]. Cancer Res, 2006, 66(7): 3593-3602.
  • 7Tan Y, Raychaudhuri P, Costa R H. Chk2 mediates stabilization of the FoxM1 transcription factor to stimulate expression of DNA repair genes[J]. Mol Cell Biol, 2007, 27(3): 1007-1016.
  • 8Wierstra I, Alves J. FOXMlc transactivates the human c-myc promoter directly via the two TATA boxes P1 and P2[J]. FEBS J, 2006, 273(20): 4645-4667.
  • 9Niwa H, Miyazaki J, Smith A G. Quantitative expression of Oct-3/4 defines differentiation, dedifferentiation or self- renewal of ES cells[J]. Nat Genet, 2000, 24(4): 372-376.
  • 10Mitsui K, Tokuzawa Y, Itoh H, et al. The homeoprotein Nanog is required for maintenance of pluripotency in mouse epiblast and ES cells[J]. Cell, 2003, 113(5): 631-642.

同被引文献46

  • 1张红绪,曹静,周庆峰,赵鹏,金白洁,王亚威,刘琦,李成伟.蜂毒素-SP94杂合基因原核表达载体的构建及蛋白纯化[J].河南师范大学学报（自然科学版）,2011,39(3):122-125. 被引量：4
  • 2李慧.细胞凋亡及细胞凋亡因子Fas系统与肿瘤[J].解放军医药杂志,1998,20(4):296-299. 被引量：1
  • 3Siegel R, Naishadham D, Jemal A. Cancer statistics, 2012 [J]. CA Cancer J Clin,2012,62( 1 ) :10.
  • 4Chandran UR, Ma C, Dhir R, et al. Gene expression profiles of prostate cancer reveal involvement of multiple molecular pathways in the metastatic process[J]. BMC Cancer,2007, 12(7) :64.
  • 5Tan Y, Raychaudhuri P, Costa RH. Chk2 mediates stabiliza- tion of the FoxM1 transcription factor to stimulate expres- sion of DNA repair genes[J]. Mol Cell Biol,2007,27 ( 3 ) : 1007.
  • 6Wang IC, Meliton L, Ren X, et al. Deletion of Forkhead Box M1 transcription factor from respiratory epithelial cells in- hibits pulmo:mry tumorigenesis [ J]. PLoS One,2009 4 ( 8 ) : e6609.
  • 7Park H J, Cart JR, Wang Z, et al. FoxM1, a critical regulator of oxidative stress during oncogenesis[J]. EMBO J, 2009, 28(19) :2908.
  • 8Park H J, Gusarova G, Wang Z, et al. Deregulation of FoxMlb leads to tumour metastasis[J] EMBO Mol Med, 2011,3(1) :21.
  • 9Bao B, Wang Z, Ali S, et al. Over-expression of FoxM1 leads to epithelial- mesenehymal transition and cancer stem eell phenotype in pancreatic eaneer cells [ J ]. J Cell Bio- ehem,2011,112(9) :2296.
  • 10公小迪,姜斌.FoxMl转录因子在肿瘤研究中的新进展[J].现代肿瘤学,2012,20(1):165.

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分子诊断与治疗杂志
2011年 第5期

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