癌症恶病质小鼠脂肪代谢的实验研究

Experimental Study on Lipid Metabolism in Cancer Cachexia Mice

目的:探讨癌症恶病质小鼠脂肪代谢的机制。方法:建立C57小鼠癌症恶病质模型,观察恶病质小鼠的一般状况,如体重、摄食量、饮水量变化;观察TG、CHOL及TNF-α、Leptin水平。结果:恶病质组小鼠体重较正常组显著减轻(P<0.05);摄食量和饮水量都较正常组减少(P<0.05);TG及CHOL均较正常组明显升高(P<0.01);TNF-α较正常组升高(P<0.01),而Leptin较正常组降低(P<0.01)。Leptin与TNF-α无相关性(P>0.05)。结论:癌症恶病质脂肪代谢机制可能与TNF-α、Leptin等细胞因子有关。

Objective：To explore the mechanism of lipid metabolism in cancer cachexia mice.Methods：Twelve C57 Lewis lung cancer model were established.Physical conditions as body weight,food and water intake were observed and the serum levels of triglyceride（TG）,cholesterol,and tumor necrosis factor α（TNF-α） and leptin were measured.Other 12 Lewis mice served as controls.Results：In the cancer cachexia group,the body weight of was lighter（P0.05）and the food and water intake was less（P0.05）;the serum levels of TG and cholesterol were significantly increased（P0.01）;the level of leptin was lower（P0.01）,while TNF-α was higher（P0.01）,as compared with that of the normal mice.No correlation was noted between TNF-α and Leptin（P0.05）.Conclusion：The mechanism of lipid metabolism of cancer cachexia may related with cytokines as TNF-α and Leptin.