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钙离子通道与老龄心房颤动心房电重构的研究进展 被引量：5

Advances in Research of Calcium Channel Current and Atrial Electrical Remodeling of Atrial Fibrillation
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摘要 随着心房颤动电生理机制研究的广泛深人,已经认识到离子通道重构在心房颤动的发生和维持过程中起重要作用。L-型钙通道及其基因表达的改变可能是老年人容易发生心房颤动电生理重建的离子和分子基础。现就心脏钙离子通道及年龄与心房颤动的研究进展予以综述。 It is important to recognize that atrial fibrillation（AF） modifies the calcium channel of the atrium promotes its occurrence and maintenance.Changes of L-type calcium channels and their gene expression in the elderly may explain ion electrophysiology and molecular reconstruction in AF.This review analyzes the relationship between the heart calcium channel current and AF in the aged.
作者 李耀东 汤宝鹏
机构地区 新疆医科大学第一附属医院心脏起搏电生理科
出处 《心血管病学进展》 CAS 2011年第5期718-720,共3页 Advances in Cardiovascular Diseases
关键词 心房颤动 钙离子通道 心房电重构 老龄 atrial fibrillation calcium channel atrial electrical remodeling elderly
分类号 R541.75 [医药卫生—心血管疾病] R331.38 [医药卫生—人体生理学]
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参考文献3

二级参考文献30

  • 1Bosch RF,Scherer CR,Rub N,et al.Molecular mechanisms of early electrical remodeling transcriptional downregulation of ion channel subunits reduces ICA L and Ito in rapid atrial pacing in rabbits[J].J Am Coll Cardiol,2003,41(5):858-867.
  • 2Xu J,Cui G,Esmailian F,et al.Atrial extra cellular matrix remodeling and the maintenance of atrial fibrillation[ J].Circulation,2004,109(3):363-368.
  • 3Brundel BJ,van-Gelder IC,Henning RH,et al.Ion channel remodeling is related to intraoperative atrial effective refractory periods in patients with paroxysmal and persistent atrial fibrillation[J].Circulation,2001,103(4):684-690.
  • 4Brundel BJ,Henning RH,Kampinga HH,et al.Molecular mechanisms of remodeling in human atrial fibrillation[J].Cardiovas Res,2002,54(2):315-326.
  • 5Cao KJ,Xia XJ,Shan QJ,et al.Changes of sarcoplasmic reticular Ca^2+-ATPase and IP3-I receptor mRNA expression in patients with atrial fibrillation[J].Chin Med J,2002,115(5):664-670.
  • 6Ehrlich JR,Cha TJ,Zhang L,et al.Characterization of a hyperpolarization-activated time-dependent potassium current in canine cardio myocytes from pulmonary vein myocardial sleeves and left atrium.J Physiol,2004,557(6):583-597.
  • 7Cha TJ,ehrilich JR,Zhang L,et al.Dissociation between ionic remodeling and ability to sustain atrial fibrillation during recovery from experimental congestive heart failure[ J].Circulation,2004,109(5):412-418.
  • 8Yamada J,Ohkusa T,Nao T,et al.Up regulation of inositol 1,4,5-trisphosphate receptor expression in atrial tissue in patients with chronic atrial fibrillation[ J].J Cardiol,2002,39(1):57-58.
  • 9Cha TJ, Ehrlich JR, Zhang L, et al. Dissociation between ionic remodeling and ability to sustain atrial fibrillation during recovery from experimental congestive heart failure. Circulation, 2004,109: 412-418.
  • 10Brundel BJ, Kampinga HH, Henning RH. Calpain inhibition prevents pacing induced cellular remodeling in a HL-1 myocyte model for atrial fibrillation. Cardiovasc Res, 2004, 62: 521-528.

共引文献5

同被引文献49

  • 1欧妍,牛小麟,任付先,张颖,凌凤东.L型钙通道_α1C亚单位在成年大鼠心脏中的表达[J].第一军医大学学报,2005,25(11):1400-1404. 被引量：6
  • 2宋艳东,杨新春,刘泰槰,顾忠伟,李志忠.源于右室流出道的室性心律失常的电生理机制研究[J].中国心脏起搏与心电生理杂志,2007,21(1):47-50. 被引量：6
  • 3于倩,葛志强.钙调神经磷酸酶抑制剂的研究进展[J].中国生化药物杂志,2007,28(3):210-212. 被引量：3
  • 4赵晟;杨水祥.心脏电重构的影响及意义进展[J]中华临床医师杂志,2013(19):8874-8877.
  • 5Kato T,Iwasaki Y,Giordanetto F. Does T-type Calcium Channel Blockade Protect against Atrial Fibrillation Related Remodeling[A].2012.
  • 6Chen WJ,Yeh YH,Lin KH. Molecular characterization of thyroid hormone-inhibited atrial L-type calcium channel expression:implication for atrial fibrillation in hyperthyroidism[J].Basic Research in Cardiology,2011,(02):163-174.
  • 7Nattel S,Dobrev D. The multidimensional role of calcium in atrial fibrillation pathophysiology:mechanistic insights and therapeutic opportunities[J].European Heart Journal,2012,(15):1870-1877.
  • 8van Oort RJ,McCauley MD,Dixit SS. Ryanodine receptor phosphorylation by calcium/calmodulin-dependent protein kinase Ⅱ promotes life-threatening ventricular arrhythmias in mice with heart failure[J].CIRCULATION,2010,(25):2669-2679.
  • 9Yamashita T,Inoue H,Okumura K. Randomized trial of angiotensin Ⅱ-receptor blocker vs.dihydropiridine calcium channel blocker in the treatment of paroxysmal atrial fibrillation with hypertension (J-RHYTHM Ⅱ study)[J].EUROPACE,2010,(04):473-479.
  • 10Neef S,Dybkova N,Sossalla S. CaMKII-dependent diastolic SR Ca2 + leak and elevated diastolic Ca2 + levels in right atrial myocardium of patients with atrial fibrillation[J].Circulation Research,2010,(06):1134-1144.

引证文献5

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心血管病学进展
2011年 第5期

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