气道慢性炎症疾病激素抵抗机制的研究进展

Advances in glucocorticoid resistance research in chronic airway inflammatory diseases

糖皮质激素广泛应用于气道慢性炎症性疾病,但部分患者对激素治疗疗效较差,存在激素抵抗。关于激素抵抗的分子机制,目前已有许多研究,本文就这一领域的研究进展进行综述,主要包括细胞因子激活丝裂素活化蛋白激酶通路,激素受体β的表达增加,组蛋白去乙酰化酶的活性下降,转录因子的调节,促白介素10分泌细胞和白介素10,T辅助细胞17和白介素17等方面。

Glucocorticoid is widely used in chronic airway inflammatory diseases,however,some patients respond poorly to it.This article summarizes in the advances of glucocorticoid resistance research,including activation of mitogen-activated protein kinase pathways by certain cytokines,increased glucocorticoid receptor-β expression,reduced histone deacetylase-2 activity,regulation of the transcription factors,IL-10 secreting Tregs and IL-10,Th17 and IL-17,and so on.