耐左氧氟沙星大肠埃希菌的耐药性分析

Analysis on drug resistance of Escherichia coli resistant to Levofloxacin

目的了解本院临床分离的大肠埃希菌的耐药情况,分析耐左氧氟沙星细菌的耐药性。方法对2009年8月至2010年8月本院临床分离的154株大肠埃希菌用Kirby-Bauer琼脂扩散法进行药物敏感试验。结果 154株大肠埃希菌中共检出耐左氧氟沙星菌76株,检出率49.35%。在各类标本中,尿液中耐左氧氟沙星菌株分离率最高(51.32%),其次为痰(23.68%)。除亚胺培南、美罗培南、头孢西丁、哌拉西林/他唑巴坦和阿米卡星外,耐左氧氟沙星菌株对氨苄西林、头孢唑啉、头孢吡肟、头孢噻肟、头孢他啶、庆大霉素、头孢哌酮/舒巴坦的耐药率明显高于非耐左氧氟沙星菌株(P<0.05)。结论本院耐左氧氟沙星大肠埃希菌株对多种药物表现出较高的耐药率,应加强对耐左氧氟沙星大肠埃希菌的耐药性监测,严格掌握抗菌药物的使用指征,防止耐药菌株的传播流行。

Objective To investigate the isolated rate of Escherichia coli among Zigong First Peoples’ Hospital and analyze the drug resistance of strains resistant to Levofloxacin.Methods Kirby-Bauer’s detection technique was applied to detect the resistance feature in 154 strains of Escherichia coli collected from August 2009 to August 2010.Results Total of 76 strains resisted to Levofloxacin were detected in 154 strains of Escherichia coli,with the detection rate as 49.35%.Among the specimens,the isolated rate of strains resistant to Levofloxacin in urina was the highest （51.32%） and the second was in sputum （23.68%）.Except for imipenem,mlopenem,cefoxitin,piperacillin/tazobatan and amikacin,the resistance rate of Levofloxacin-resistant strains were significantly higher than that of non-Levofloxacin-resistant strains to ampicillin,cefazolin,cefepime,cefotaxime,ceftazidime,gentamycin,cefoperazone/sulbactam（P 0.05）.Conclusions Levofloxacin-resistant Escherichia coli is resistant to many antibacterial agents.Monitoring of Levofloxacin-resistant strains should be strengthened and the indication of antibiotics must be mastered strictly to prevent the dissemination of drug resistant strains.