Raman光谱法与经典方法验证尼群地平固体分散体

Verifying Nitrendipine solid dispersion by Raman spectrometry and the classical methods

目的:用Raman光谱法和经典方法(红外光谱法和X-射线衍射法)研究尼群地平固体分散体的分散性,以期获得1种新的、简单易行的检查固体分散体分散性的方法。方法:采用溶剂法制备尼群地平固体分散体,用显微共焦拉曼光谱仪、傅里叶变换红外光谱仪和X-射线衍射仪分别采集尼群地平、PVP K30,尼群地平∶PVP K30(1∶6)的物理混合物及尼群地平固体分散体的拉曼图谱、红外图谱和X-射线衍射图谱,并进行对比分析。结果:3种鉴别方法得到一致的结果:尼群地平以分子状态分散在固体分散体中。结论:拉曼光谱法快速、直接、对样品无损伤,是1种新的、理想的检查固体分散体分散性的方法。

Objective：To study the dispersivity of Nitrendipine solid dispersion by Raman spectrometry and the classical methods（infrared spectrometry and X-ray powder diffractometry） in order to obtain a new and simple method in examining the dispersivity of solid dispersion.Methods：Nitrendipine solid dispersion was prepared by solvent method.The Raman spectra,infrared spectra and X-ray powder diffraction patterns of Nitrendipine,PVP K30,physical mixture,solid dispersion were acquired by Raman and Fourier transform infrared spectrometers and X-ray powder diffractometry.And the spectra were compared with each other in order to find out the differences between Nitrendipine solid dispersion and other materials.Results：The three methods obtained the same results that Nitrendipine was dispersed in the carrier as the state of molecule.Conclusion：Raman spectrometry is an ideal method in identifying the dispersivity of solid dispersion which is fast,direct and non-destructive for samples.