神经丛蛋白A2(PLXNA2)基因多态性与精神分裂症的关联研究

Association study of Plexin A2(PLXNA2) gene polymorphisms with schizophrenia

目的:探讨神经丛蛋白(PLXNA2)基因与汉族人群精神分裂症的关联。方法:采用DNA测序检测方法,依据ICD-10诊断标准,在735例汉族精神分裂症住院患者和1316例年龄、性别匹配的正常对照者中,探索PLXNA2基因5个单核苷酸多态性(SNP)位点与精神分裂症的关联。结果:PLXNA2基因的4个SNPs位点与精神分裂症关联(均P<0.05);由rs3811383-rs841865-rs2785622组成的单体型ATT及由rs841865-rs752016组成的单体型AC与精神分裂症关联(均P<0.05)。结论:本研究结果提示PLXNA2基因多态性在中国汉族人群中与精神分裂症关联。

Objective： To explore the association of the PLXNA2 gene polymorphisms with schizophrenia. Methods： Five single nucleotide polymorphisms （SNPs） of PLXNA2 gene were analyzed in a sam- ple of 735 schizophrenic patients and 1 334 healthy controls of Chinese Han, using direct DNA sequencing meth- od. The diagnoses were made according to the the International Statistical Classification of Diseases and Related Health Problems 10th Revision （ ICD-10）. Results： Four SNPs were found to be associated with schizophrenia （rs3811383,X2 =7. 89, P =0. 005; rs1409831,x2 =6. 75, P =0. 009; rs2785622,X2 =3. 85, P =0. 049; rs841865,X2 = 3.92, P = 0. 047）. Haplotypes consisted by rs3811383 - rs841865 - rs2785622 and rs841865 - rs752016 were also associated with schizophrenia （ATT,x2 = 7. 88, P = 0. 005; AC,x2 = 4. 20, P = 0. 040）. Conclusion： These findings provide further evidence for PLXNA2 as a predisposing gene involved in schizophrenia in the Chinese Han popula- tion.