摘要
The aim of this experiment was to determine the pharmacokinetics of hydrochloric idazoxan in deers plasma alter intramuscular （IM） dosing. Six clinical healthy Cervus nippon Temmincks were injected with the idazoxan solution at the dose of 0.44 mg·kg-1. Eight mL blood sample was taken from a jugular vein and plasma was separated for drug determination by using liquid chromatography with tandem mass spectrometric detection. Idazoxan pharmacokinetic parameters were simulated by noncompartmental analyses. The results showed that the absorption and elimination of hydrochloric idazoxan in plasma was quick by route of administration, the half-lives of absorption （t1/2Ka） and elimination （t1/2Kc） were （0.2094 ± 0.0341） min, and （13.1842±0.2353） min, respectively, the area under the plasma drug concentration-time curve from 0 to ∞ （AUC） was （0.0700±0.0035） （mg·mL-1）. min the maximum concentration in the plasma （Cmax） was （0,0047±0.0005） mg.mL ＇, peaking at （12.4618±0.1198） rain after dosing. In conclusion, these data indicated that the kinetics of hydrochloric idazoxan were fitted to one compartment model with first order absorption, which was characterized by rapid drug action, and fast metabolism with few residue in the blood.
The aim of this experiment was to determine the pharmacokinetics of hydrochloric idazoxan in deers plasma alter intramuscular （IM） dosing. Six clinical healthy Cervus nippon Temmincks were injected with the idazoxan solution at the dose of 0.44 mg·kg-1. Eight mL blood sample was taken from a jugular vein and plasma was separated for drug determination by using liquid chromatography with tandem mass spectrometric detection. Idazoxan pharmacokinetic parameters were simulated by noncompartmental analyses. The results showed that the absorption and elimination of hydrochloric idazoxan in plasma was quick by route of administration, the half-lives of absorption （t1/2Ka） and elimination （t1/2Kc） were （0.2094 ± 0.0341） min, and （13.1842±0.2353） min, respectively, the area under the plasma drug concentration-time curve from 0 to ∞ （AUC） was （0.0700±0.0035） （mg·mL-1）. min the maximum concentration in the plasma （Cmax） was （0,0047±0.0005） mg.mL ＇, peaking at （12.4618±0.1198） rain after dosing. In conclusion, these data indicated that the kinetics of hydrochloric idazoxan were fitted to one compartment model with first order absorption, which was characterized by rapid drug action, and fast metabolism with few residue in the blood.
基金
Supported by Post-doctoral Scientific Research of Heilongjiang Province (LBH-Q07016)
