摘要
目的探讨中药萎胃康逆转慢性萎缩性胃炎(CAG)的机制。方法采用多重刺激法复制慢性萎缩性胃炎动物模型,分别应用大、小剂量萎胃康及三九胃泰灌胃治疗。30 d后观察大鼠胃酸、血清胃泌素(GAS)含量及免疫组化法观察G细胞数量,光镜下观察胃黏膜病理学改变。结果萎胃康大、小剂量组及三九胃泰组均能不同程度的升高胃酸、血清GAS含量和增加G细胞数量,以萎胃康大剂量组最为明显(P<0.01)。结论中药萎胃康对CAG的疗效机制可能与升高胃酸、血清GAS含量和增加G细胞数量有关。
Objective To approach the possible mechanism of Wei wei kang-Granule（WWKG）reversing chronic atrophic gastritis（CAG）.Methods The multiple stimulations were used to duplicate the CAG model.Treat respectively with WWKG and Sanjiuwei-tai-Granule（SJWTG）.After 30 days,the contents of gastric acid and GAS in serum and the pathological changes of the gastric mucosa by gross appearance and microscopy were observed.The immunohistochemistry method was used to observe the number of G cell.Results The contents of gastric acid and GAS in serum and the number of G cell in large and small dose WWKG group and SJWTG group were all significantly higher than those in model group,especially in large dose WWKG group（P0.01）.Conclusion WWKG might treat CAG possibly by increasing the contents of gastric acid and GAS in serum and the number of G cell.
出处
《滨州医学院学报》
2011年第4期241-243,共3页
Journal of Binzhou Medical University
基金
国家自然科学基金资助项目(81072782)
