PTEN蛋白表达与人喉癌发生和预后的关系

Relation between expression of PTEN protein in human laryngeal carcinoma and its biological characteristic

目的检测PTEN蛋白在喉癌中的表达,探讨它与人喉癌的发生发展和预后的关系。方法采用SP免疫组化方法检测PTEN蛋白在79例喉癌组织、16例声带不典型增生和27例声带息肉组织中的表达。结果 PTEN蛋白在人喉癌组织中阳性率为56.96%(45/79例),在声带不典型增生病变中为75.00%(12/16例),在声带息肉中为100%(27/27)。PTEN蛋白表达阳性者5年生存率明显高于PTEN蛋白表达阴性者(P<0.01)。结论 PTEN蛋白表达与喉癌的发生、侵袭转移和预后相关,对判断喉癌的发生和预后有重要意义。

Objective To investigate the expression of PTEN protein in human laryngeal carcinoma and explore its biological characteristic.Methods SP immunohistochemistry method was used to detect and identify 79 cases of formalin-fixed and paraffin-embedded laryngeal carcinoma,16 cases of atypical hyperplasia of vocal fold and 27 cases of vocal cord polyps.Results The positive rates of PTEN protein in human laryngeal carcinoma,atypical hyperplasia of vocal cord and vocal cord polyps were 56.96%,75.00%,100% respectively and had an increasing trend.The 5 years survival rates in PTEN protein positive cases were higher than those of the negative cases（P0.01）.Conclusions The expression of PTEN protein may playan important role in the tumorigenesis,aggressiveness,metastases and prognosis of laryngeal carcinoma,which provides useful information for occurrence and prognosis of laryngeal carcinoma.