脐血IL-10、铅水平与缺氧缺血性脑病新生儿行为神经测定的关系

The relationship between IL-10 and lead concentration of umbilical cord blood with NBNA in newborn infants with hypoxic-ischemic encephalopathy

目的观察脐血白细胞介素-10(IL-10)、铅水平与缺氧缺血性脑病(HIE)新生儿行为神经测定(NBNA)的关系。方法将57例中重度HIE新生儿分为低血铅组(<60μg/L)37例及高血铅组(≥60μg/L)20例,2组分别进行脐血IL-10、铅检测及NBNA评分,观察脐血IL-10和铅水平与NBNA的关系,同时以健康新生儿28例作为健康对照组。结果 HIE组与健康对照组脐血铅含量差异无统计学意义(P>0.05);HIE组脐血IL-10水平显著高于健康对照组(P<0.01);HIE高血铅组与HIE低血铅组IL-10水平差异无统计学意义(P>0.05);HIE高血铅组比HIE低血铅组NBNA评分显著降低(P<0.05);HIE高血铅组和HIE低血铅组IL-10水平和NBNA评分均呈负相关(r分别为-0.819、-0.714,P均小于0.05)。结论提示IL-10可监测HIE患儿病情,判断预后,脐血铅含量增高可对婴儿神经行为发育产生不良影响,影响HIE患儿的预后。

Objective To explore the relationship between IL 10 and lead concentration of umbilical cord blood with neonatal be- havioral neurological assessment（NBNA） in newborn infants with hypoxic-ischemic encephalopathy（HIE）. Methods 57 newborn infants with moderate-severe HIE were divided into 2 groups,including low lead level group（~60/~g/L） （n=37） and high lead lev- el group （~60/~g/L） （n= 20）. Peripheral venous blood was collected to measure IL-10 and lead concentration and the scores of NB NA were evaluated of the two groups. Normal newborn infants were enrolled as controls. Results Compared with controls,the con- centrations of lead in HIE group were no statistical different （P^0.05） ,but the concentrations of IL-10 were higher （P^0.01）. Within HIE groups,the concentrations of IL 10 were not statistical different（P^0.05） ,but the scores of NBNA in high lead level group were lower than low lead level group（P^0.05）. The serum concentrations of IL 10 in HIE groups were negatively correlated with the scores of NBNA （r= --0. 819,--0. 714 ,P%0.05）. Conclusion Determination of serum IL-10 in infants with HIE could be with great value in illness monitoring and prognosis. There could be harmful effect of higher lead level on physical development of infants and influence the prognosis of HIE.