阿托伐他汀对冠心病患者血脂及血清炎性因子水平的影响

Effect of Atorvastatin on the Levels of Blood Fat and Serum Inflammatory Factor in Patients with Coronary Artery Disease

目的探讨阿托伐他汀对冠心病患者血脂及血清炎性因子水平的影响。方法选择2006年3-12月40例冠心病住院患者(含出院后随访),随机分为冠心病常规治疗组(常规治疗组)20例和常规治疗+阿托伐他汀治疗组(阿托伐他汀组,20mg/d)20例。用酶联免疫吸附法和常规酶法等测定两组患者治疗前及治疗后8周血脂水平〔总胆固醇(TC),低密度脂蛋白胆固醇(LDL-C),高密度脂蛋白胆固醇(HDL-C),三酰甘油(TG)〕及血清肿瘤坏死因子-α(TNF-α),基质金属蛋白酶-9(MMP-9)、C-反应蛋白(CRP)和丙二醛(MDA)的水平。结果两组患者治疗后血脂水平(TC、LDL-C、TG),血清TNF-α、MMP-9、CRP及MDA水平间差异均有统计学意义(P<0.05)。结论阿托伐他汀能显著降低冠心病患者的血脂水平,同时能减轻冠心病患者的全身炎性反应程度。

Objective To observe the effect of atorvastatin on the levels of blood fat and serum inflammatory factor in patients with coronary artery disease.Methods From 2006/3 to 2006/12,forty patients with coronary artery disease were randomized into two groups：Group A（n=20）given conventional therapy and Group B（n=20）given an additional treatment of atorvastatin besides conventional one.We determined,by enzyme linked immunosorbent assay and routine enzymic method,the serum tumor necrosisαfactor（TNF-α）,9-matrix metalloproteinase（MMP-9）,C reactive protein（CRP）,malondialdehyde（MDA） and the level of blood fat including total cholesterol（TC）,low density lipoprotein cholesterol（LDL-C）,high density lipoprotein cholesterol（HDL-C） and triglyeride（TG）before the treatment and 8 weeks after treatment.Results There was significant difference in the levels of TNF-α,MMP-9,CRP,MDA and blood fat（TC,LDL-C and TG） between the two groups.Conclusion Atorvastatin can decrease remarkably the levels of TC,LDL-C and TG,and lessen the level of inflammatory reaction in patients with coronary artery disease.