心血管疾病风险预测的相关性研究

The Correlation Research in Risk Prediction of Cardiovascular Disease

目的探讨超敏C-反应蛋白水平与动脉粥样硬化的相关性,其对于冠心病的风险预测的重要性。方法选择健康体检者65例(对照组)。冠心病组196例,其中经冠状动脉造影阳性(直径狭窄程度≥70%为阳性)113例,冠状动脉造影阴性45例,心肌梗死(AMI)38例,测定血清超敏C-反应蛋白(hs-CRP)水平。结果冠心病组hs-CRP水平明显高于健康对照组(P>0.01),其中冠状动脉造影阳性组hs-CRP水平明显高于阴性组,而AMI组hs-CRP、CK、CK-MB水平又著显高于以上其他组别。冠状动脉粥样硬化患者各亚组间hs-CRP水平比较差异有统计学意义(P<0.05)。结论 hs-CRP水平的变化对于冠心病的病情发展、变化程度呈正相关。hs-CRP可作为独立的动脉粥样硬化危险因子对冠心病、AMI的风险预测有重要临床价值。

Objective To explore the correlation of the level of high-sensitive C-reactive protein（hs-CRP） and artherosclerosis（AS）.To discuss its significance to the predication of the risk in CHD.Methods select 65 healthy as the control group.while 196 cases as the CHD group.Among which 113 cases are the coronary arteriography positive.45 cases negative.38 cases as Myocardial infarction group（AMI）.To compare the level of hs-CRP,Tn-T,CK,CK-MB in serum of the different categories.Results hs-CRP levels of CHD group significantly higher health group（P0.01）.The hs-CRP levels of coronary arteriography positive group（≥70% artery diameter stenosis to be positive） is significantly higher than the negative groups.And the hs-CRP,CK,CK-MB level of myocardial infarction group（AMI） again is shown higher than other groups.There is a statistical significance difference in the hs-CRP levels of various CHD subgroups.（AMI coronary angiography positive coronary angiography negative,P0.05）.Conclusion The level of the Hs-CRP is positively related to the development of the coronary heart disease.Hs-CRP can be used as independent risk factors for athersclerosis and coronary heart disease,it is of great clinical value to risk prediction of the myocardial infarction.