药源性急性肾衰竭22例临床分析

Drug-induced Renal Failure:A clinical report of 22 cases

目的探讨药源性急性肾衰竭的原因及引起急性肾衰竭的药物种类,为临床合理用药提供参考。方法对我院收治的22例药源性急性肾衰竭患者的资料进行回顾性分析。统计药源性急性肾衰竭患者的原发病、合并症、使用药物、给药途径。结果药源性急性肾衰竭患者的原发病主要为呼吸道感染,占41.2%,其次为发热,占13.8%;无合并疾病者占45.6%,合并高血压者占22.9%;导致药源性急性肾衰竭的药物主要有抗生素、甘露醇及化疗类药物等。结论抗生素类、甘露醇及化疗类药物是我院引起急性肾衰竭的主要常见药物,应及时予以诊断治疗,并停用可疑药物。

Objective To investigate the cause of acute drug-induced renal failure and the categories of those drugs that can cause the renal failure so as to provide the reference to reasonable usage of drugs.Methods The retrospective analysis was taken for the data of 22 inpatients with acute drug-induced renal failure in our hospital,including the primary diseases,complications,drug usage and route of medication.Results The patients with acute drug-induced renal failure whose primary disease was respiratory infection accounted for 40.9%,next,those whose primary disease was fever counted for 13.6%.The patients without complication accounted for 45.6%.The patients whose complication was hypertension accounted for 22.7%.The drugs that cause acute drug-induced renal failure mainly include antibiotics,mannitol and species for chemotherapy.Conclusion Antibiotics,mannitol and species for chemotherapy are most common drugs to cause acute renal failure in our hospital;the patients should be given immediate diagnosis and treatment;and the questionable drugs should be stopped.