脑梗死与颈动脉粥样硬化斑块及危险因素分析

Analysis of cerebral infarction with carotid atherosclerotic plague and risk factors

目的探讨脑梗死与颈动脉粥样硬化(CAS)斑块及血脂、纤维蛋白原(FIB)、尿酸(UA)、C-反应蛋白(CRP)水平的关系。方法对108例经头颅CT或MRI确诊的急性脑梗死患者(脑梗死组)和86例健康体检者(对照组)进行颈动脉颅外段彩色多普勒超声检查,观察斑块情况。同时检测2组血脂、FIB、UA及CRP水平。结果脑梗死组CAS斑块检出率为77.78%高于对照组的19.77%,差异有统计学意义(P<0.01)。脑梗死组血清总胆固醇(TC)、低密度脂蛋白(LDL)、FIB、UA及CRP水平明显高于对照组(P<0.05);且有斑块亚组上述指标水平明显高于无斑块亚组(P<0.05)。结论 CAS斑块是脑梗死发生的重要因素,TC、LDL、FIB、UA及CRP水平增高是脑梗死及CAS斑块形成的危险因素。

Objective To discuss the relationship among cerebral infarction and carotid atherosclerosis（CAS） plague,levels of plasma lipid and fibrinogen（FIB）、serum uric acid（UA）、C-reactive protein（CRP）.Methods 108 cases patients with cerebral infarction were detected by CT or MRI（cerebral infarction group）,and 86 cases healthy（control group） were detected by color Doppler.To check the plague,the level of plasma lipid、FIB、UA and CRP in two groups.Results Rate of plague in cerebral infarction group（77.78%） was significantly higher than that in control group（19.77%）（P0.01）;The level of total cholesterol（TC）、low density lipoprotein（LDL）、 FIB 、UA and CRP in cerebral infarction group were significant higher than those in control group（P0.05）,and in cerebral infarction with plaque subgroup were significantly higher than those in cerebral infarction without plaque subgroup（P0.05）.Conclusion CAS plague is a key factor of the occurrence of cerebral infarction.High levels of TC、LDL、FIB、UA and CRP are risk factors of cerebral infarction and CAS.