2010年实验用鼠健康状况的病理学调查和分析

Investigation and Analysis of Pathology on Health Status of Experimental Rats in 2010

应用石蜡切片及H.E染色法,于2010年5月和10月分别对10家和14家实验动物单位的4～6周龄实验用鼠的心、肝、脾、肺、肾、大肠和小肠进行组织学观察。结果显示,绝大多数的实验用鼠为健康动物,而非健康动物以脂肪肝和轻度肺炎为主要病变,且发病率稳定。这可能与饲养的环境和饲料有关,加强饲养管理可以使这种情况得到改善。

In May 2010 and October 2010,we have taken 219 and 230 rats from 10 and 14 units respectively to investigate the health status of experimental rats.All of these rats were killed by cutting off the cervical.We collected the heart,lung,liver,spleen,kidney,large intestine and small intestine,and then put these organs into 10% paraformaldehyde solution for fixation.The samples were then observed with optical microscopy.The results show that the vast majority of experimental mice were pathologically diagnosed as healthy animals.Fatty liver and bronchial pneumonia are the two main lesions which affect the health of laboratory animals.The reason may be breeding and feeding environment and we can improve the management to ameliorate the health status of experimental rats.