摘要
以三甲基羟乙基氯化铵作为可溶性载体,支载氰基乙酸酯,与硫及醛或酮经Gewald反应合成了10种2-氨基噻吩类化合物,产率为55%~91%,产物经红外光谱及核磁共振分析,与其结构相吻合.该方法操作简单,产物分离纯化方便,解脱下来的季铵盐结构没有遭到破坏,可循环使用.
The research of the use of task-specific onium salt as soluble support for the Gewald synthesis of 2-aminothiophenes was reported in this article. This synthetic method was simple and efficient, and the products were obtained in good to excellent yields (55 %- 91 %) with high purities, without the need for chromatographic purification, and the onium salt could be recycled.
出处
《湖北大学学报(自然科学版)》
CAS
北大核心
2011年第3期293-296,共4页
Journal of Hubei University:Natural Science
基金
国家自然科学基金(20772026)资助