静脉输液不良反应报告分析

Analysis of intravenous infusion adverse drug reation reports

目的分析静脉输液药物不良反应（ADR）的发生特点和规律，为临床合理用药、安全输液提供参考。方法对2009年1月至2011年2月门诊和急诊上报的83例静脉输液ADR报告进行分类统计分析。结果发生静脉输液ADR的83例患者中，女性[44例（53．0％）]和老年患者[40例（48．2％）]较多见；发生率在前3位的药物依次为抗微生物药[45例（54．2％）]、中药注射剂[16例（19．3％）]和血制品及血浆代用品[9例（10．8％）]；主要累及器官为皮肤及附件、消化系统及神经系统等。结论需重视门急诊静脉输液ADR，加强监测，指导临床合理用药，减少和避免静脉输液ADR的发生，保障用药安全。

Objective To analyze the characteristics and laws of intravenous infusion adverse drug reaction （ADR） reports of out-patient/emergency on 83 cases in our hospital and to provide the reference of rational use of drugs and safe transfusion. Methods A statistical analysis was conducted based on 83 cases of drug intravenous infusion ADR which were reported from January 2009 to February 2011. Results In the 83 cases, women were 44 cases（53.0% ） and elderly patients were 40 cases（48.2% ）. The top three drugs of ADR incidence were antimicrobial drugs （54.2%）, traditional Chinese medicine injection（ 19.3% ）and adjuvant therapies and plasma substitute （10.8%）. The mainly involving organs were skin, accessories, digestive and nervous system. Conclusions We should pay attention to intravenous infusion ADR of out-patient/emergency. Management of monitoring should be strengthened to ensure safety of drug use.