慢性阻塞性肺疾病患者血小板参数变化及临床意义

The clinical significance of platelet parameter changes in patients with chronic obstructive pulmonary disease

目的探讨血小板参数在慢性阻塞性肺疾病(COPD)中的变化及临床意义。方法对确诊为COPD的患者128例,分别测定急性加重期及治疗后缓解期的85例的血小板计数(PLT)、血小板平均体积(MPV)、血小板分布宽度(PDW)及大血小板比率(P-LCR),并与136例健康老年人血小板参数结果进行比较。结果 COPD急性加重期PLT、P-LCR明显低于正常对照组(P<0.05),MPV明显低于缓解期组(P<0.01);缓解期组各项参数与正常对照组无明显差异(P>0.05)。结论监测血小板参数对COPD患者病情判断及指导治疗具有一定的意义。

Objective To investigate the changes of platelet parameter in patients with chronic obstructive pulmonary disease （COPD）. Methods The p!atelet total （ PLT）, mean platelet volume （ MPV）, platelet distribution width （PDW） and platelet -large cell ratio（ P- LCR） were measured in 128 cases during acute exacerbation of COPD and 85 cases of stable COPD. It was compared with 136 cases of healthy elders. Results PLT and P - LCR in patients with acute exacerbation of COPD were lower than those of healthy elders significantly （P 〈 0. 05 ） , MPV was lower than that of stable COPD significantly （P 〈 0. 01 ）, The platelet parameter was no significantly difference between stable C OPD and healthy elders （P 〉 0. 05 ）. Conclusion The detection of platelet parameter can be valuable to judgement of disease progress and instructing the treatment of COPD.