氟桂利嗪对缺血性脑血管病患者血浆同型半胱氨酸水平的干预研究

Study on the effect of flunarizine to plasma homocysteine among ischemic cerebrovascular disease patients

目的探讨血浆同型半胱氨酸(Hcy)水平与缺血性脑血管病的关系,以及氟桂利嗪对缺血性脑血管病患者血浆Hcy水平的影响。方法将174例患者分为缺血性脑血管病组(134例,其中脑梗死90例,短暂性脑缺血发作组44例)和对照组(40例),检测所有受试对象血浆Hcy水平并记录患者的脑血管病传统危险因素。将缺血性脑血管病患者随机分为常规治疗组及联合氟桂利嗪治疗组,观察2组治疗前后血浆Hcy水平的变化。分析血浆Hcy水平与缺血性脑血管病的相关性及氟桂利嗪对患者血浆Hcy水平的影响。结果缺血性脑血管病组、脑梗死组与TIA组患者血浆Hcy水平均高于对照组(P<0.05),脑梗死与TIA患者相比血浆Hcy水平差异无统计学意义(P>0.05);治疗前后常规治疗组与联合氟桂利嗪治疗组患者血浆Hcy水平差异无统计学意义(P>0.05);联合氟桂利嗪治疗前后患者血浆Hcy水平差异无统计学意义(P>0.05)。结论血浆Hcy水平升高可能是与传统危险因素无关的缺血性脑血管病的独立危险因素,氟桂利嗪不能通过降低血浆Hcy水平对缺血性脑血管病的预后产生影响。

Objective To determine the relationship between plasma homocysteine（Hcy） and ischemic cerebrovascular disease（ICVD）and the effect of flunarizine to plasma homocysteine among ischemic cerebrovascular disease patients.Methods One hundred and seventy-four patients were divided into the group of ICVD,including 90 patients with cerebral infarction and 44 patients with transient ischemic attack（TIA）,and control group.The level of Hcy was detected and traditional risk factors of all patients were recorded.The group of ICVD were divided into two groups.One was given standard stroke prevention therapy,the other was added fulanarizine.This paper analyzed the relationship between Hcy and ICVD,so did the effect of flunarizine to plasma homocysteine among ICVD patients.Results The levels of Hcy in the patients with ischemic cerebrovascular disease,cerebral infarction and TIA were higher than control group（P0.05）,but there was no difference in the level of Hcy between patients with cerebral infarction and TIA（P0.05）.There was no difference in the level of Hcy between the patients given fulanarizine or without（P0.05）.Conclusion Increasing Hcy may be an independent risk factor of ICVD,which has no correlation with traditional risk factors.The prognosis of ICVD can＇t be improved by flunarizine decreasing Hcy.