血清胃蛋白酶原在胃癌及胃癌前病变诊断中的意义

The value of serum PG in diagnosis of gastric cancer and gastric precancerous lesions

目的探讨胃蛋白酶原(PG)Ⅰ、PGⅡ水平和PGⅠ/PGⅡ比值变化对胃癌前病变及胃癌诊断的价值。方法选择2008年5月至2011年3月因消化道症状做胃镜检查的门诊及住院患者共539例,根据胃镜检查及组织病理学结果,将受检者分为5组。胃溃疡124例为胃溃疡组,浅表性胃炎130例为浅表性胃炎组,萎缩性胃炎102例为萎缩性胃炎组,胃癌90例为胃癌组,体检证实无胃、肠、心、肝、肾等疾病史93例为正常组,比较各组血清PGⅠ、PGⅡ水平。结果与正常组相比较,慢性浅表性胃炎组、胃溃疡组血清PGⅠ、PGⅡ、PGⅠ/PGⅡ水平显著升高(P<0.01),慢性萎缩性胃炎组、胃癌组血清PGⅠ、PGⅠ/PGⅡ水平著降低(P<0.01)。结论血清PGⅠ、PGⅡ水平以及PGⅠ/PGⅡ比值对提高胃癌及胃癌前病变的诊断有重要的临床价值。

Objective To evaluate the clinical value of the serum levels of pepsinogenⅠ（PGⅠ）,pepsinogenⅡ（PGⅡ） and PGⅠ/PGⅡin diagnosis of gastric cancer and gastric precancerous lesions.Methods 539 cases were included in the study.According to the results of gastroscopy and histopathology,these patients were divided into five groups,gastric ulcer group with 124 cases,superficial gastritis group with 130 cases,atrophic gastritis group with 102 cases,gastric cancer with 90 cases,and normal group with 93 cases,and then the serum levels of PGⅠ,PGⅡ of each group are compared.Results The PGⅠ level of gastric ulcer patients was significantly higher than that of healthy group and the other groups（P0.01）.The PGR in CAG and GC patients was significantly lower than that in the other groups（P0.01）.Conclusion The plasma levels of the serum levels of PGⅠ,PGⅡand PGⅠ/PGⅡ play an important value in diagnosis of gastric cancer and gastric precancerous lesions.