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Ⅰ期乳腺癌保乳术后乳腺三维适形加速外照射的临床研究

Accelerated partital-breast Irradiation using 3-dimensional conformal external-beam radiation therapy (APBI-3DCRT) in early breast cancer after beast conserving surgery
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摘要 目的探讨Ⅰ期乳腺癌保乳术后乳腺三维适形加速外照射(APBI-3DCRT)治疗的近期疗效。方法选择2003年2月至2006年3月在湖北省肿瘤医院行Ⅰ期乳腺癌保乳术后患者89例,自愿接受APBI-3DCRT治疗的患者57例为APBI-3DCRT组,全乳腺照射(WBI)治疗的患者32例为WBI组。使用8 MV光子线进行APBI-3DCRT和WBI计划设计,设定4～5个照射野,处方剂量为每次3.4 Gy,每天2次,间隔6 h,总剂量34 Gy。观察两组患者的生存率、复发率、急性放射性损伤发生率和乳房美容效果。结果 APBI-3DCRT组急性放射性皮肤反应发生率和肺损伤发生率(10.53%和5.26%)较WBI组(28.13%和18.75%)低(P<0.05)。APBI-3DCRT组乳房美容优良率(92.98%)较WBI组(75.00%)高(P<0.05)。结论Ⅰ期乳腺癌保乳术后APBI-3DCRT治疗近期疗效好。 Objective To evaluate the clinical feasibility of APBI-3DCRT in stageⅠbreast cancer after breast conserving surgery.Methods 57 patients were treated with APBI-3DCRT voluntarily as APBI-3DCRT group,and 32 patients treated with whole breast irradiation as WBI group,and all of cases were from Feb 2003 to Mar 2006 in Hubei Tumor Hospital APBI-3DCRT and WBI were designed by means of the photon beans with energy of 8 MN,and four to five irradiation fields were set,the prescri-ption dose was about 3,4 Gy with 2 times per day at intervals of 6 hours,the total dose was 34 Gy.Survival rate,recurrence rate,acute irradiation skin responses,irradiation lung injury and breast appearance after the two therapies were appraised.Results The 5-year local recurrence rate,5-year metastasis rate and 5-year survival rate of APBI-3DCRT group was 5.26%、3.51% and 100%,respectively,which was of no significant difference with WBI group（P0.05）.The acute irradiation skin responses rate of APBI-3DCRT and WBI group was 10.53% and 28.13%,the irradiation lung injury rate of the two groups were 5.26 %and 18.75%.The breast appearance excellent rate of APBI-3DCRT and WBI group was 92.98% and 75.00%（P0.05）.Conclusion APBI-3DCRT is feasible for stageⅠbreast cancer patients after conserving surgery.
作者 陈卫东 吴毅平
机构地区 湖北省肿瘤医院放疗介入科 华中科技大学同济医院美容整形科
出处 《重庆医学》 CAS CSCD 北大核心 2011年第27期2724-2725,2728,共3页 Chongqing medicine
关键词 乳腺肿瘤 放射疗法 乳腺三维适形加速外照射 breast neoplasms radiotherapy after breast-conserving surgery Accelerated partial breast irradiation 3-dimensional conformal radio-therapy
分类号 R737.9 [医药卫生—肿瘤]
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参考文献16

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共引文献6

重庆医学
2011年 第27期

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