帕利哌酮和奥氮平治疗精神分裂症急性期的对照研究

Comparative study for treatment with Paliperidone release tablets and Olanzapine in schizophrenia

目的比较帕利哌酮和奥氮平治疗精神分裂症急性期的疗效及不良反应。方法选择本院2010年1月至2011年1月住院精神分裂症急性期患者66例,随机分为帕利哌酮组(n=32),予帕利哌酮初始剂量为6 mg/d,可在1～2周根据病情及耐受性,加至9 mg/d或下调至3 mg/d,如果下调到3 mg/d后耐受但疗效不佳,可以调回到6 mg/d,平均剂量为(6.25±2.75)mg/d。奥氮平组34例,予奥氮平初始剂量5 mg/d,1周内加至10 mg/d。比较两组疗效。结果帕利哌酮起效较快,但奥氮平对焦虑抑郁、缺乏活动及行为障碍等症状疗效较好。帕利哌酮使患者体质量增加轻微,对代谢影响较小。奥氮平使患者泌乳及月经紊乱发生率低于帕利哌酮。结论帕利哌酮与奥氮平治疗精神分裂症急性期均有效,且不良反应少,安全性高。

Objective To compare the efficacy and side effects of Paliperidone release tablets and Olanzapine in treating acute schizophrenia.Methods 68 patients with acute schizophrenia were randomly assigned to the group treated with Paliperidone release tablets（32 cases） or Olanzapine（34 cases）.The initial dosage of paliperidone release tablets was 6 mg/d which could be adjusted 9 mg/d or 3 mg/d according to the situation of the patients and their tolerance.The average usage was（6.25±2.75）mg/d.To the olanzapine group,the initial dosage was 5 mg/d,and increased to 10 mg/d within one week.And then effects of the two groups were compared.Results Paliperidone release tablets got the efficacy rapidly.Olanzapine was better than Paliperidone release tablets in treating anxiety,depression,lacking of energy and behavior disorders.There were not serious adverse reactions in the duration of treatment.The advantage of Paliperidone release tablets wsd less weight gain.The advantage of Olanzapine was less lactation and menstrual disorder.Conclusion The treatment of Paliperidone release tablets and Olanzapine in acute schizophrenia is effective,with few side effects and safe..