独活寄生汤加减结合运动疗法治疗膝骨关节炎的临床研究

Clinical study on the varied dosages of DUHUO JISHENG DECOCTION combined with exercise therapy in the treatment of knee osteoarthritis

目的:观察独活寄生汤加减结合运动疗法治疗膝骨关节炎的临床疗效。方法:将符合要求的128例患者随机分为2组,每组64例。治疗组采用独活寄生汤加减结合运动疗法治疗,对照组单纯采用独活寄生汤加减治疗。分别于治疗后1个月和治疗后12个月时按照林志雄等制定的膝关节综合评分表,从关节休息痛、运动痛、肿胀、压痛、活动度及行走情况6个方面对患者进行疗效评定。结果:治疗后1个月,2组患者疗效比较,差异无统计学意义(Z=-0.498,P=0.618);治疗后12个月治疗组疗效优于对照组(Z=-2.648,P=0.008)。结论:独活寄生汤加减结合运动疗法治疗膝骨关节炎疗效持久、稳定,值得临床推广应用。

Objective：To observe the clinical curative effects of the varied dosages of DUHUO JISHENG DECOCTION combined with exercise therapy in the treatment of knee osteoarthritis.Methods：One hundred and twenty-eight patients met the criteria were randomly divided into 2 groups,64 cases in each group.Patients in the treatment group were administrated with the varied dosages of DUHUO JISHENG DECOCTION combined with exercise therapy,while the others in the control group were administrated with varied dosages of DUHUO JISHENG DECOCTION only.According to the knee comprehensive score sheet which was formulated by Lin Zhixiong,the curative effects of the patients were evaluated from the following 6 aspects as joint rest pain,joint motion pain,joint swelling,joint tenderness,joint range of motion and walking conditions 1 month and 12 months after the treatment respectively.Results：One month after the treatment,there was no statistical difference in the curative effects between the two groups（Z=-0.498,P=0.618）,while 12 months after the treatment,the curative effects of treatment group were better than those of control group（Z=-2.648,P=0.008）.Conclusion：The method of varied dosages of DUHUO JISHENG DECOCTION combined with exercise therapy has a long-lasting and stable curative effect in the treatment of knee osteoarthritis,it is worth popularizing in clinic.