摘要
建立了大鼠坐骨神经分支选择性损伤实验(SNI)模型,通过观察大鼠机械刺激阈值考察新型芳烷酮哌嗪衍生物YX0611-1对神经病理性疼痛的抑制作用。结果表明,YX0611-1以80 mg/kg灌胃给药明能显著提高SNI模型大鼠的机械痛阈值,与阳性对照药加巴喷丁(100 mg/kg)的镇痛效果无显著差异(P>0.05),提示该化合物对神经病理性疼痛具有较好的治疗作用。
The spared nerve injury （SNI） rat model was established to investigate the analgesic effect of the novel aralkyl-ketone piperazine derivative-YX0611-1 on neuropathic pain by determining paw withdrawal mechanical threshold. The results showed that YX0611-1 significantly improved the mechanical threshold in SNI rats by intragastric administration. The analgesic effects of YX0611-1 （80 mg/kg） and positive control gabapentin （100 mg/kg） had no significant difference （P〉0.05）. The results indicated that the compound YX0611-1 had an analgesic effect on neuropathic pain.
出处
《中国医药工业杂志》
CAS
CSCD
北大核心
2011年第9期669-671,共3页
Chinese Journal of Pharmaceuticals
基金
国家“重大新药创制”科技重大专项(2009ZX09301-007)
