2010年湖北省部分地区健康人群百日咳、白喉、破伤风人群免疫水平分析

Surveillance on Immuning Levels Against Pertussis,Diphtheria and Tetanus Among Healthy Population in Some Areas of Hubei Province in 2010

目的了解湖北省人群免疫状况,评价预防接种质量和效果,制定免疫对策。方法分七个年龄组抽取黄石和咸宁两个地区部分健康人群,采用ELISA法定量检测正常人血清中百日咳、白喉和破伤风IgG抗体水平。结果两个地区健康人群中,百日咳IgG抗体阳性率为27.14%,白喉和破伤风IgG抗体安全保护率分别为55.71%和60.29%。结论抽取的湖北省两个地区健康人群百日咳、白喉和破伤风IgG抗体阳性率均比较低,提示要扩大接种覆盖率,缩短强化免疫周期,提高冷链运转效率和疫苗接种质量。

Objective To investigate the immunization status among the population in Hubei Province,to evaluate the quality and effectiveness of immunization,and to develop immunization strategies.Methods The serum samples collected from healthy population of Huangshi and Xianning were divided into seven age-groups.And serum IgG antibody levels against pertussis,diphtheria and tetanus were determined by ELISA.Results Among the healthy population,the positive rate of serum IgG antibody against pertussis was 27.14%,the protective rates of diphtheria and tetanus were 55.71% and 60.29%,respectively.Conclusions The antibody positive rates of pertussis,diphtheria,and tetanus are lower in the two areas of Hubei Province,which indicate that it is necessary to expand the vaccination coverage rate,shorten immuning cycle,and improve the efficiency of cold chain transport and the quality of vaccine inoculation.