微卡辅助治疗新涂阳肺结核疗效分析

Analysis on Adjuvant Efficacy of Mycobacterium Vaccae on Treatment of New Smear-positive Pulmonary Tuberculosis

目的观察和评价微卡联合常规化疗药物治疗新涂阳肺结核的疗效。方法 302例新涂阳肺结核患者被随机分为治疗组和对照组,每组各151例,治疗组给予2HRZE/4H3R3加用微卡菌苗治疗6个月,对照组只用2HRZE/4H3R3治疗6个月,观察治疗后肺部病灶吸收率、痰菌阴转率、微卡治疗不良反应情况。结果治疗2、4、6月末时,治疗组病灶吸收率明显高于对照组,差异均有统计学意义(P<0.05)。治疗组和对照组2、3、5、6月末时,治疗组痰菌转阴率明显高于对照组,差异均有统计学意义(P<0.05)。接受微卡治疗无严重不良反应。结论微卡联合常规化疗药物治疗新涂阳肺结核病人可显著增强常规化疗效果,有助于病灶吸收好转、痰菌转阴,且有较好的安全性,可作为新涂阳肺结核的辅助治疗。

Objective To observe and evaluate the effect of mycobacterium vaccae combined with conventional chemotherapy drugs in the treatment of new smear-positive pulmonary tuberculosis.Methods Three hundred and two new smear-positive TB patients were randomly divided into treatment group and control group（each n=151）.The treatment group received 2HRZE/4H3R3 plus mycobacterium vaccae treatment for 6 months and the control group only received 2HRZE/4H3R3 treatment for 6 months.The absorption rate of lung lesions,the sputum conversion rate and the adverse reactions of mycobacterium vaccae were observed.Result The differences of lung lesions absorption rate of two groups at the end of 2,4 and 6 months of treatment were statistically significant（P0.05）.The lung lesions absorption rate of treatment group was significantly higher than that of control group.The differences of sputum conversion rate of two groups at the end of 2,3,5 and 6 months of treatment were statistically significant（P0.05）.The sputum conversion rate of treatment group was significantly higher than that of control group.No serious adverse reactions were observed in receiving Mycobacterium vaccae treatment.Conclusions Mycobacterium vaccae combined with conventional chemotherapy drugs can significantly enhance the effect of conventional drugs on new smear-positive pulmonary tuberculosis patients.It helps to improve absorption of lung lesions and sputum conversion rate,and moreover has a good security.Mycobacterium vaccae can be used as adjuvant therapy on new smear-positive pulmonary tuberculosis patients.