比亚芬在预防鼻咽癌放射性皮肤损伤中的临床疗效观察

Clinical Therapeutic Effects of Biafine Cream in Preventing Irradiation-induced Dermal Injury

目的探讨比亚芬在预防鼻咽癌放射性皮肤损伤中的临床效果。方法将首次接受放射治疗的73例鼻咽癌患者随机分为两组,观察组37例与对照组36例,观察组在放疗开始即应用比亚芬,对照组不予应用。观察比较两组患者放射性皮肤损伤发生情况。结果所有患者均发生不同程度的放射性皮肤损伤,观察组放射性皮肤损伤Ⅲ级及以上发生率为8.10%(3/37),对照组为30.56%(11/36),对照组明显高于观察组,差异有统计学意义(P<0.05);在40Gy照射剂量之前,对照组出现放射性皮肤损伤24例,观察组出现8例,两组比较差异有统计学意义(P<0.01)。结论比亚芬可以有效预防鼻咽癌患者严重放射性皮肤损伤的发生,保证放射治疗的顺利进行,并具有较好的安全性。

Objective To explore the clinical effects of Biafine cream in preventing irradiation-induced dermal injury.Methods Seventy-three patients with nasopharyngeal carcinoma who initially received radiotherapy were randomly divided into observation group（n=37） and control group（n=36）.Biafine cream was applied in observation group since the first radiotherapy session,while the other 36 cases were not given this medication.The situation of irradiation-induced dermal injury in the two groups was observed and compared.Results The incidence rate of severe irradiation-induced dermal injury（≥Ⅲ） in observation group was significantly lower than that in control group（8.10% vs 30.56%）,and the difference was statistically significant（P0.05）.Before receiving the irradiation doses of 40 Gy,24 cases with irradiation-induced dermal injury were found in control group and 8 cases found in observation group,there were statistically significant differences between the two groups（P0.01）.Conclusions Biafine cream can effectively prevent the irradiation-induced dermal injury and ensure the progress of radiation therapy;moreover,it is safe.