岳阳市2009-2010年结核分枝杆菌耐药情况分析

Analysis on Drug Resistance of Mycobacterium tuberculosis in Yueyang from 2009 to 2010

目的分析岳阳市近两年一线抗结核药的耐药状况,为耐药结核病预防控制提供依据。方法对岳阳市2009年1月-2010年12月就诊的结核患者,临床分离株培养鉴定为结核分枝杆菌的菌株采用绝对浓度法进行一线抗结核药:异烟肼(INH)、利福平(RFP)、链霉素(SM)、乙胺丁醇(EMB)耐药性检测,分析结核分枝杆菌的耐药情况。结果 205例结核患者中,总耐药率和总耐多药率分别为32.7%、18.8%;初始耐药率和获得性耐药率分别为21.3%、63.6%;获得性耐多药率38.2%,明显高于初始耐多药率10.7%。结论岳阳市结核耐药状况仍然比较严重,应进一步加强耐药结核的监测和控制。

Objective To analyze the drug resistance of antibiotics frequently used for treating tuberculosis in Yueyang in recent two years,and to provide the evidence for tuberculosis controlling.Methods The patients infected with Mycobacterium tuberculosis（MTB） diagnosed in Yueyang from January,2009 to December,2010 were enrolled in this study.Absolute concentration method was used to test the drug-resistance of isoniazide（INH）,rifampicin（RFP）,streptomycin（SM）,and ethambutol（EMB）.Results Among 205 patients infected with MTB,the total rates of drug resistance and multi-drug resistance were 32.7% and 18.8%,respectively.The rates of initial drug resistance and acquired drug resistance were 21.3% and 63.6%,respectively.The acquired multidrug-resistant rate was 38.2%,which was significantly higher than that of initial multidrug-resistant rate（10.7%）.Conclusions The drug resistant status of tuberculosis is still serious in Yueyang,and we should further monitor and control the drug resistance of antibiotics in treating tuberculosis.