庆大霉素局部注射治疗女性尿道综合征的临床研究

Local injection of gentamycin for female urethral syndrome:A clinical study

目的:研究在"女性前列腺"局部注射抗生素对女性尿道综合征的疗效,为其探索一种有效的治疗方法。方法:选择2009年7月至2010年12月在我院门诊就诊的患者,共入选163例。根据就诊顺序前瞻性随机分为A、B、C 3组,A组58例为实验组,B组55例、C组50例为对照组。A、B、C 3组均进行同样的常规治疗,除此之外A、B组同时采取局部注射治疗,A组注射庆大霉素8万单位(2 ml)+2%利多卡因2 ml的混合药液,B组注射生理盐水2 ml+2%利多卡因2 ml的混合药液。注射方法两组完全一致。浸润性注射在尿道后壁尿道旁腺及其周围,每周治疗2次,6次为1疗程。根据患者自主症状评分的改变评定疗效。疗程结束后第2、4周重复症状评分,症状消失为治愈,分值减少>1/2为为显效,分值减少>1/4分为有效,分值减少<1/4或者反增加为无效。结果:疗程结束后第2周症状评分,疗效A组(有效率为77.5%)明显高于B组(有效率为67.3%)和C组(有效率为68.0%),差异有显著性(P<0.05),而B、C组间无明显差异(P>0.05)。疗程结束后第4周复查,A组有效率略有下降,仍然高于B组和C组,差异有显著性(P<0.05)。结论:"女性前列腺"局部注射庆大霉素治疗女性尿道综合征有一定效果。

Objective： To observe the therapeutic effect of local antibiotic injection into the female prostate on female urethral syndrome（FUS）,and search for an effective treatment for this disease.Methods： This study included 163 FUS patients treated in the out-patient department between July 2009 and December 2010.According to the visiting order,the patients were randomly assigned to Groups A（n = 58）,B（n = 55） and C（n = 50）.All underwent routine treatment.Inaddition Group A received local injection of 2 ml of 80 000 U gentamycin ＋ 2 ml of lidocaine,and Group B 2 ml of normal saline ＋ 2 ml of lidocaine,both injected into the distal segment of the urethral back wall where the female prostate is located,twice a week for 3 weeks.The therapeutic effects were evaluated according to the changes of the patients＇ independent symptom scores at 2 and 4 weeks after the treatment.Disappearance of the symptoms was considered as ＂curative＂,1/2 reduction in the symptom score as ＂obviously effective＂,1/2-1/4 reduction in the symptom score as ＂effective＂,and 1/4 reduction or increase in the symptom score as ＂ineffective＂.Results： At 2 weeks after the treatment,the total effectiveness rate was significantly higher in Group A（77.5%） than in B（67.3%） and C（68.0%）（P 0.05）,but with no statistically significant difference between B and C（P 0.05）.At 4 weeks,the total effectiveness rate of Group A was slightly decreased,but still remarkably higher than that of Group B or C（P 0.05）.Conclusion： Local injection of gentamycin into the female prostate is effective for the treatment of female urethral syndrome.