丙泊酚联和咪达唑仑用于ICU机械通气镇静治疗的临床观察

Clinical Observation of Combined Propofol and Midazolam for Sedation Therapy in ICU Mechanical Ventilation

目的:评价丙泊酚联和咪达唑仑在ICU机械通气镇静治疗中的效果。方法:将69例患者随机分为两组:观察组(丙泊酚-咪达唑仑联和组)35例和对照组(咪达唑仑组)34例,观察两组治疗前后心率、平均动脉压、呼吸、血氧饱和度变化、药物起效时间、停药后苏醒时间、达到满意镇静深度时间及不良反应。结果:两组治疗前后生命体征有明显变化(P<0.05)。观察组药物起效时间、停药后苏醒时间、达到满意镇静深度时间均比对照组短,两组比较差异有统计学意义(P<0.05)。停药后观察组出现恶心2例,对照组6例;观察组出现血压下降6例,对照组5例。结论:丙泊酚和咪达唑仑联用有着很好的镇静效果,不良反应少,可安全有效地应用于ICU机械通气的镇静治疗。

Objective： To evaluate the effect of combined use of propofol and midazolam for sedation therapy in ICU mechanical ventilation Methods： Sixty-nine patients were randomly divided into two groups： study group（combined propofol and midazolam） with 35 cases and control group（midazolam group） with 34 cases.Heart rate,mean arterial pressure,respiration,oxygen saturation,drug onset time,wake time of drug withdrawal,the time of achieved satisfactory sedation and side effects were observed before and after the treatment.Results： There were significant differences between the two groups in signs of life before and after treatment（P0.05）.Compared to the control group,there were shorter onset time and recovery time after treatment,as well as the time of achieved satisfactory sedation（P0.05）.Two cases of nausea after drug withdrawal were observed in study group whereas 6 cases in control group.Blood pressure instability was observed in 6 patients in the study group and 5 cases in the control group.Conclusions： Combined use of propofol and midazolam which showed satisfied sedative effect with lower adverse reactions was safe and effective in sedation therapy in ICU mechanical ventilation.