拉氧头孢钠治疗细菌性脑膜炎的临床体会

Clinical Experience of Bacterial Meningitis Treated by Latamoxef Sodium

目的：观察拉氧头孢钠治疗细菌性脑膜炎的临床疗效和安全性。方法：回顾性调查分析近5年我院治疗细菌性脑膜炎的病历,随即抽取拉氧头孢钠50mg/kg治疗组20例（A组）和头孢吡肟50 mg/kg对照组20例（B组）,1次/12 h,疗程均为5~14 d。比较两组临床疗效、细菌学改变及不良反应情况。结果：A、B两组的临床痊愈率分别为90.00%、85.00%,A、B两组的临床有效率分别为95.00%、90.00%,二者比较差异无统计学意义（P〉0.05）。结论：拉氧头孢钠治疗细菌性脑膜炎的疗效满意,不良反应少,药物安全性高,在新农合和城镇医保范围,可对医疗机构及患者取得双赢,值得在临床推广应用。

Objective： To observe the clinical efficacy and safety of bacterial meningitis treated by latamoxef sodium.Methods： Retrospective investigation to the bacterial mengitis cases in our hospital in the past 5 years was taken.Forty cases were randomly selected and divided into the latamoxef sodium 50 mg/kg treatment group（group A） and the cefepime 50 mg/kg control group（group B）,each with 20 cases.Then the clinical efficacy,bacteriological changes and adverse reactions were compared between the two groups.Results： The clinical efficacy of group A and B was 95.00% and 90.00% respectively,without significant difference（P0.05）.Conclusion： Latamoxef sodium treating bacterial meningitis,which had higher efficacy,safety and less adverse reaction,could reach a win-win situation for both the medical institutions and the patients under the system of new rural cooperative medicare scheme and urban health insurance.It is wealthy of clinical application.