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肠道炎症阻滞儿童体格生长的免疫和内分泌机制 被引量：1

Intestinal inflammation-induced child growth failure: immunologic and endocrine mechanisms
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摘要 肠道炎症常伴发儿童的生长落后。生长激素(GH)和胰岛素生长因子-1(IGF-1)是调控出生后骨骼纵向生长的重要物质,抑制GH/IGF轴可阻滞儿童体格生长。肠道发生炎症时,异常升高的促炎症因子IL-1β、IL-6和TNF-α通过干扰GH/IGF轴,系统性以及在生长板局部水平影响骨骼生长,进而导致儿童生长阻滞。 Faltering linear growth is commonly encountered in children with intestinal inflammation.Growth hormone（GH） and insulin-like growth factor-1（IGF-1） are important regulators of postnatal longitudinal bone growth.Inhibition of GH/IGF axis will result in growth failure in young children.Pro-inflammatory cytokines such as interleukin-1β（IL-1β）,tumor necrosis factor-α（TNF-α） and interleukin-6（IL-6） abnormally increase in children with intestinal inflammation,and may affect linear growth both systemically and locally at the level of the growth plate though disturbing the GH/IGF axis.
作者 马静秋 盛晓阳
机构地区 上海交通大学医学院附属新华医院儿童与青少年保健科上海市儿科医学研究所上海市环境与儿童健康重点实验室
出处 《中国当代儿科杂志》 CAS CSCD 北大核心 2011年第9期767-770,F0003,共5页 Chinese Journal of Contemporary Pediatrics
关键词 肠道炎症 促炎症因子 生长激素/胰岛素生长因子轴 生长落后 儿童 Intestinal inflammation Pro-inflammatory cytokine Growth hormone/insulin-like growth factor axis Growth failure Child
分类号 R725.7 [医药卫生—儿科]
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参考文献51

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二级参考文献34

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共引文献12

同被引文献16

  • 1于意,王伟,王莹,黄嶶,董治亚,滕月春,倪继红,肖园,王德芬.生长激素受体基因多态性与特发性矮小遗传易感性的关系[J].上海交通大学学报（医学版）,2011,31(7):932-936. 被引量：12
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中国当代儿科杂志
2011年 第9期

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