摘要
目的：检测申克孢子丝菌酵母相对7种抗真菌药物的体外敏感性.方法：应用美国临床与实验室标准化研究所（CLSI）颁布的M27-A2方案检测15株临床分离的申克孢子丝菌对伊曲康唑、特比萘酚、氟康唑、酮康唑、咪康唑、两性霉素B及5-氟胞嘧啶的体外最小抑菌浓度（MIC）.结果：特比萘酚对申克孢子丝菌酵母相的体外敏感性最高,几何平均值为0.144,其次为酮康唑0.710.氟康唑与5-氟胞嘧啶的敏感性较差,分别为16和15.47.结论：特比萘酚对申克孢子丝菌酵母相有较高的抑菌活性.至于是否具有较好的体内治疗效果,需要进性体内体外抗真菌的相关性研究.
Objective ： To determine the antifungal susceptibilities of the yeast -like forms of Sporothrix schenckii; Methods ： 15 clinical isolates of Sporothrix schenckii to 7 drugs using a microdilution method. The susceptibility was approved by the Committee of International Laboratory Standards （CILS） . Results ： The MICs of Terbinatine were significantly higher than others for the yeast - like forms. Conclusion ： Terbinafine have a significant inhibition against Sporothrix schenekii in vitro.
