期刊文献+

PET—CT下三维适形放疗Ⅲ期非小细胞肺癌的预后分析 被引量:6

Outcome and prognostic factors in stage Ⅲ non-small-cell lung cancer treated with definitive radiation therapy with
原文传递
导出
摘要 目的探讨在PET—CT指导下行三维适形放疗(3DCRT)的Ⅲ期非小细胞肺癌(NSCLC)的疗效和预后因素。方法对59例在PET—CT定位下行3DCRT的Ⅲ期NSCLC患者,采用Kaplan—Meier法计算生存率并Logrank法检验和单因素预后分析,对单因素分析有意义的因素进一步行Cox模型多因素预后分析。结果随访率为98%,随访满2年者为19例。1、2年生存率分别为66%、37%,中位生存期17个月。单因素分析结果显示影响预后的因素有吸烟、放疗剂量、大体肿瘤体积、SUV值、T分期、临床分期(X^2=7.46、7.52、8.37、4.97、5.82、4.37,P=0.006、0.006、0.004、0.026、0.016、0.037)。Cox模型多因素分析显示影响预后的因素有吸烟、放疗剂量、大体肿瘤体积、临床分期(X^2=6.20、9.69、6.39、10.09,P=0.013、0.002、0.011、0.001)。结论PET—CT定位下行3DCRT的Ⅲ期NSCLC患者的生存时间优于以往报道,吸烟、放疗剂量、大体肿瘤体积、临床分期是影响生存的因素。 Objective To investigate prognostic factors in Stage Ⅲ non-small cell lung cancer (NSCLC) treated with definitive radiation therapy (RT) with PET-CT-based radiotherapy planning. Methods Fifty nine patients with Stage Ⅲ NSCLC treated with radiation therapy of 60 Gy or more were enrolled into this study. The impact of prognostic factors on survival was evaluated by univariate and multivariate analyses. Results The following-up rate was 98%. Nineteen patients completed 2 years' followed-up. The overall 1-year and 2-year survival rate was 66% and 37% , respectively, with a median survival time of 17 months. At a univariate analysis, cigarette smoking status, T stage, radiation dose, the standardized uptake value, the gross tumor volume and clinical stage were significant prognostic factors (X^2 = 7.46,7.52,8.37,4.97,5.82,4. 37,P = 0. 006,0. 006,0. 004,0. 026,0. 016,0. 037, respectively). At multivariate analyses, cigarette smoking status, radiation dose, gross tumor volume and clinical stage were significant prognostic factors ( X^2 = 6. 20, 9.69, 6. 39, 10.09, P = 0. 013,0. 002, 0. 011,0. 001, respectively). Conclusions Cigarette smoking status, radiation dose, gross tumor volume and clinical stage are significant prognostic factors on survival in patients with Stage Ⅲ NSCLC treated with RT based on PET-CT radiotherapy planning.
出处 《中华放射肿瘤学杂志》 CSCD 北大核心 2011年第5期390-393,共4页 Chinese Journal of Radiation Oncology
基金 辽宁省科学技术计划项目(2006225007-5)
关键词 体层摄影术 正电子发射 非小细胞肺/放射疗法 放射疗法 三维适形 预后 Tomography, positron-emission Carcinoma, non-small-cell lung/radiotherapy Radiotherapy, three-dimensional conformal Prognosis
  • 相关文献

参考文献18

  • 1Jemal A, Siegel R, Xu J, et al. Cancer statistics,2010. CA Cancer J Clin,2010,60:277-300.
  • 2Jett JR, Scott WJ, Rivera MP, et al. American college of chest physicians. Guidelines on treatment of stage ⅢB non-small cell lung cancer. Chest,2003,123 Suppl 1 : 221-225.
  • 3Robinson LA, Ruckdeschel JC, Wagner H Jr, et al. American college of chest physicians. Treatment of non-small cell lung cancer-stage ⅢA :ACCP evidence-based clinical practice guidelines (2nd edition). Chest,2007,132 Suppl 3:243-265.
  • 4Ung YC, Maziak DE, Vanderveen JA, et al. Lung cancer disease site group of cancer care ontario's program in evidence-based care. ^18 Fluorodeoxyglucose positron emission tomography in the diagnosis and staging of lung cancer: a systematic review. J Natl Cancer Inst ,2007,99 : 1753-1767.
  • 5Deniaud-Alexandre E, Touboul E, Lerouge D, et al. Impact of computed tomography and ^18F-deoxyglucose coincidence detection emission tomography image fusion for optimization of conformal radiotherapy in non-small-cell lung cancer. Int J Radiat Oncol Biol Phys,2005,63 : 1432-1441.
  • 6Heron DE, Andrade RS, Beriwal S, et al. PET-CT in radiation ontology: the impact on diagnosis, treatment planning, and assessment of treatment response. Am J Clin Oncol,2008,31 : 352- 362.
  • 7Weber WA, Dietlein M, Hellwig D, et al. PET with (18) F- fluorodeoxyglucose for staging of non-small cell lung cancer. Nukleannedizin ,2003,42 : 135-144.
  • 8MacManus MP, Hicks RJ, Matthews JP, et al. High rate of detection of unsuspected distant metastases by PET in apparent stage Ⅲ non small cell lung cancer: implications for radical radiation therapy. J Radiat Oncol Biol Phys,2001,50 :287-293.
  • 9Kong FM, Ten Haken RK, Schipper M J, et al. High-dose radiation improved local tumor control and overall survival in patients with inoperable/unresectable non-small cell lung cancer: long-term results of a radiation dose escalation study. Int J Radiat Oncol Biol Phys,2005,63 : 324-333.
  • 10Rengan R, Rosenzweig KE, Venkatraman E, et al. Improved local control with higher doses of radiation in large-volume stage Ⅲ non-small cell lung cancer. Int J Radiat Oncol Biol Phys, 2004, 60:741-747.

同被引文献43

引证文献6

二级引证文献35

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部