肿瘤翻译调控蛋白在人乳腺癌组织中的表达及临床意义

Expression of translationally controlled tumor protein in human breast cancer and its clinical significance

目的探讨人肿瘤翻译控制蛋白(TCTP)在浸润性乳腺癌组织中的表达情况并分析TCTP表达与临床病理特征的关系。方法采用链霉素-生物素过氧化物酶免疫组织化学法检测94例浸润性乳腺癌及正常乳腺组织中TCTP蛋白的表达水平。结果浸润性乳腺癌组织中TCTP蛋白的阳性表达率显著高于癌旁正常乳腺组(P<0.001),TCTP的表达水平与乳腺癌肿瘤直径、临床分期、组织分级以及淋巴结转移情况密切相关(P<0.05),而与乳腺癌患者年龄、不同组织学类型之间的关系无统计学意义(P>0.05)。乳腺癌肿瘤直径愈大、临床分期愈高,乳腺癌组织中TCTP的表达阳性率也愈高;且有淋巴结转移者的TCTP阳性表达率明显高于无淋巴结转移者(P=0.003)。生存期分析显示,TCTP表达阳性的患者生存时间(52.0±3.7)月明显短于阴性表达的患者(88.6±3.6)月,(P<0.001)。结论 TCTP的异常表达参与了乳腺癌的演进过程,并且是乳腺癌患者预后不良的一个独立指标。

Objective To investigate the expression of translationally controlled tumor protein（TCTP） in human breast cancer tissues and its clinical significances.Methods The expression of TCTP in 94 human breast cancer and the corresponding adjacent normal mammary tissues were detected using immunohistochemistry.Results The expression rate of TCTP was 64.89% in human breast cancer tissues,significantly higher than that in normal benign mammary tissues（39.36%,P〈0.001）.TCTP overexpression was positively correlated to the tumor size,clinical stage,lymph node metastasis and histological grade of breast cancer（P〈0.05）.Patients with positive TCTP expression had a significantly shorter mean survival time than those with negative expression（P〈0.001）.Conclusion TCTP may play an important role in the tumorigenesis and development of breast cancer,and can be an important prognostic factor for this malignancy.