666例维汉老年男性骨代谢水平、骨密度测定分析

Measurement and analysis of bone metabolism level and bone mineral density in 666 elderly Han and Uygur men

目的探讨汉族和维吾尔族老年男性骨代谢水平的特点,了解一定年龄范围内男性骨质疏松的特点。方法选择符合研究对象的666名老年汉族和维吾尔族男性,测量骨密度(BMD)、骨碱性磷酸酶(BAP)、骨钙素(BGP)、抗酒石酸酸性磷酸酶(TRACP-5b)、25羟基维生素D3(25-(OH)VD3),按BMD值分为正常组、骨量减少组和骨质疏松组并进行比较。结果 OP患病率随年龄增加而增加,与年龄呈正相关。单因素方差分析,维吾尔族、汉族老年男性在年龄、BGP、TRACP-5b中差异有统计学意义(P<0.05)。统计学两两比较:汉族老年男性骨质疏松组TRACP-5b高于正常组及骨量减少组,骨质疏松组BGP骨量明显高于正常组(P<0.05);维吾尔族骨量减少组的25-(OH)VD2、25-(OH)VD3与正常组存在差异,维吾尔族老年男性骨质疏松组年龄明显高于正常组。同组比较中:正常组、骨质疏松组中,维吾尔族25-(OH)VD2、25-(OH)VD3水平明显低于汉族(P<0.05),正常组中维吾尔族老年男性BAP、BGP水平高于汉族老年男性(P<0.05);同组中,维吾尔族年龄均低于汉族年龄(P<0.05)。结论 BGP、TRACP-5b在汉族老年男性中可以较早的反应骨代谢水平的差异性,可以作为骨质疏松症的早期检测指标;维吾尔族老年男性和汉族老年男性在维生素D代谢上可能存在着差异并影响到骨代谢。

Objective To study the characteristics of bone metabolism level and osteoporosis in a certain age range in elderly men of Han and Uygur nationalities. Methods Six hundred and sixty-six elderly men of Han and Uygur nationalities were selected as research subjects. BMD and serum BAP, BGP, TRACP-5b, 25-（OH）VD2, and 25-（OH） VD3 were measured. The subjects were divided into normal density group, osteopenia group, and osteoporosis group according to BMD. Results OP prevalence increased with age, and was positively correlated with age. Single factor analysis of variance revealed that the differences of age, BGP, and TRACP-5b between Uygur and Han elderly men were statistically significant （ P 〈0. 05 ）. TRACP-5b in Uygur and Han osteoporosis group was higher than that in normal group or osteopenia group. BGP in osteoporosis group was higher than that in normal density group （P 〈 0. 05 ）. Serum 25-（OH） VD2 and 25-（OH） VD3 were different between Uygur osteopenia group and normal density group. The age of osteoporosis eider men group was significantly higher than that of normal group. In the same groups, levels of 25 （OH） VD2 and 25 （OH） VD3 in Uygur normal and osteoporosis groups were significantly lower than those in Han groups （P 〈 0. 05）. Levels of BAP and BGP in Uygur elder men normal density group were higher than those in Han （ P 〈 0.05 ）. In the same group, the age of Uygur was lower than that of Han（ P 〈 0. 05）. Conclusion BGP and TRACP-5b in Han elder men may reflect the difference of bone metabolism level earlier, and they may be used as early detection marker of osteoporosis. Differences may exist between Uygur and Han elder men in vitamin D metabolism and these may influence the bone metabolism.