胰腺导管内乳头状黏液瘤的研究进展

Progress in research of intraductal papillary mucinous neoplasms

胰腺导管内乳头状黏液瘤(intraductal papillary mucinous neoplasm,IPMNs)为来源于胰腺导管上皮的分化程度多样的胰腺肿瘤,位于主胰管或其分支内,可分泌黏液,为胰腺癌的癌前病变.区分IPMNs的良恶性对制定治疗方案,预估患者预后意义重大.随影像学和内镜的发展,IPMNs发现率逐年提高,但目前仍无敏感度和特异度均高的术前IPMNs良恶性评估标准.超声内镜引导下细针穿刺活检(endoscopic ultrasonography guided fine-needle aspiration,EUS-FNA)及内镜逆行胰胆管造影(endoscopic retrograde cholangio-pancreatography,ERCP)在IPMNs诊断中的应用逐渐增多,但必要性尚存在争议.本文对IPMN研究进展进行综述,并总结文献中良恶性IPMNs可能存在的差异.

Intraductal papillary mucinous neoplasms （IPMNs） represent a spectrum of neoplasms arising from the main pancreatic duct or branch ducts and producing mucin and can be regarded as a type of precancerous lesions. Thanks to improvements in endoscopy and imaging techniques, IPMNs are being diagnosed with increasing frequency. However, there are currently no highly sensitive and specific preoperative criteria available to distinguish benign IPMNs from malignant ones. What＇s more, the necessity for EUS and ERCP in the diagnosis of IPMNs is still under debate. Here, we review recent advances in research of IPMNs and summarize potential differences between benign and malignant IPMNs