口腔使用氯己定与呼吸机相关肺炎发病关系的系统评价

Oral chlorhexidine administration and ventilator-associated pneumonia:a meta-analysis

目的分析口腔使用氯己定对呼吸机相关肺炎(VAP)的预防作用。方法检索PubMed等数据库,查找所有对比使用氯己定和空白对照患者VAP发病率的随机对照研究,应用Review Manager 5.0分析软件,对所选文献结果进行综合分析。结果共纳入9项随机对照研究。口腔使用氯己定可降低VAP发病率(OR=0.44,95%CI 0.32～0.62),但不能有效地降低患者病死率(OR=1.04,95%CI 0.79～1.83)。结论口腔使用氯己定可降低VAP发病率。

Objective To investigate the association of oral chlorhexidine rinse with incidence of ventilator-associated pneumonia （VAP）. Methods We searched PubMed as well as references lists from publications to collect randomized controlled trials comparing oral chlorhexidine with placebo in their effects on incidence of VAP. Meta analysis was performed using software Review Manager 5.0. Results Nine randomized controlled trials were included. Oral chlorhexidine rinse resulted in a reduced incidence of VAP （OR=0.44, 95%CI 0.32- 0.62）. There was no difference in mortality rate between patients receiving oral chlorhexidine rinse and placebo （OR=1.04, 95%CI 0.79-1.83）, Conclusion The available evidence indicates that oral chlorhexidine rinse can reduce incidence of VAP.