非动脉型肺动脉高压的临床诊治进展

Recent advances in the diagnosis and treatment of non-pulmonary arterial hypertension pulmonary hypertension

肺动脉高压(PH)是以肺血管阻力增高为特点的一类疾病,PH作为一个血流动力学改变过程可以见于多种疾病过程中。非动脉型肺动脉高压(non-PAH PH)是指根据肺动脉高压的最新分类属于第2～5大类的疾病,主要包括左心疾病相关PH、肺部疾病相关PH、慢性栓塞性PH等。PAH患者通常病情凶险而预后严重不良,目前PH的临床及基础研究主要关注于动脉型肺动脉高压(PAH)领域,但是临床相对少见,而non-PAH PH临床上更为常见,对于non-PAH PH的研究将是目前及今后PH研究领域的热点和难点之一。

Pulmonary hypertension（PH） is a heterogeneous group of disorders characterized by increased pulmonary vascular resistance（PVR）. The term PH pertains to the hemodynamic profile. PH can be found in different clinical conditions. The non-pulmonary arterial hypertension pulmonary hypertension（non-PAH PH） refers to those forms of PH that are found in group 2 to 5 of the current classification of PH. They included pulmonary hypertension due to left heart disease, pulmonary hypertension due to lung diseases and hypoxemia, chronic thromboembolic pulmonary hypertension, and other diseases. Some advances has been made for the diagnosis and medical therapy of pulmonary arterial hypertension（PAH）, but PAH is usually severe and overall quite rare. Non-PAH PH is much more common than PAH, and has been less well studied, especially in terms of diagnosis and medical therapy. The diagnosis and medical therapy of non-PAH PH would be the hot topics and it is important to conduct further studies.