新型绿色室温离子液体催化合成monastrol及其衍生物

A new green room temperature ionic liquid catalyzes synthesis of monastrol and its derivatives through Biginelli reaction

目的探索操作简便的monastrol及其衍生物的绿色合成方法。方法以(取代)苯甲醛、乙酰乙酸乙酯和硫脲(或尿素)作为起始原料,在微波加热、无溶剂条件下,采用自行设计的绿色室温离子液体1-丁基-3-甲基咪唑-L-樟脑磺酸盐催化Biginelli反应合成monastrol及其衍生物。结果该离子液体在微波加热、无溶剂条件下可催化Biginelli反应合成monastrol及其衍生物,且操作过程简单、反应时间短、环境友好。结论以新型绿色室温离子液体1-丁基-3-甲基咪唑-L-樟脑磺酸盐作为催化剂,经微波、无溶剂Biginelli反应合成monastrol及其衍生物是一种方法简单、操作方便、反应温和的绿色合成方法。

Objective To explore an easily-controllable,environmentally-friendly method for synthesizing monastrol and its derivatives.Methods Monastrol and its derivatives were synthesized using（substituted） benzaldehyde,ethyl acetoacetate and thiourea（or urea） as the material through a Biginelli reaction catalyzed by green room temperature ionic liquid 1-butyl-3-methylimidazolium-L-camphorsulfonate under microwave irradiation without solvent.Results The green room temperature ionic liquid 1-butyl-3-methylimidazolium-L-camphorsulfonate catalyzed Biginelli reaction in obtaining the title compound under microwave irradiation without solvent.The process was easy to operate,time saving and environmentally-friendly.Conclusion Microwave-accelerated solvent-free Biginelli reaction using green room temperature ionic liquid 1-butyl-3-methylimidazolium-L-camphorsulfonate as catalyst is a convenient and environmentally-friendly method for synthesizing monastrol and its derivatives.