山东省2007-2010年人群出生缺陷监测结果分析

Birth defects in Shandong,China,2007-2010

目的了解山东省人群出生缺陷发生情况,为今后监测工作的管理重点和制定出生缺陷预防措施提供依据。方法对2007-2010年山东省人群出生缺陷监测的数据进行率及顺位等分析。应用Visual FoxPro 6.0建立数据库,采用SPSS 15.0软件进行数据分析。结果 2007-2010年人群出生缺陷发生率分别为107.44/万、82.86/万、141.29/万和124.64/万,年度间人群出生缺陷发生率比较差异有统计学意义(P<0.01);人群出生缺陷发生率顺位从高到低依次为先天性心脏病、多指(趾)、总唇裂、脑积水、神经管缺陷、肢体短缩等。结论山东省人群出生缺陷发生率在逐年上升,男性高于女性;出生缺陷先天性心脏病居首位,有逐年上升趋势。

Objective To analyze the occurrence of birth defects based on clinical outcomes of new born babies in Shandong province and provide scientific basis for early diagnosis and intervention.Methods The records of birth defects were collected for the year of 2007-2010.Visual FoxPro6.0 was applied to set up a database and SPSS15.0 was used for statistical analysis.Results The prevalence rates of birth defects were 107.44,82.86,141.29 and 124.64 per ten thousand newborns for the year of 2007-2010,repectively.The highest prevalence rate of birth defect was congenital heart disease（41.06/10 000）,followed by polydactyly（11.41/10 0000）,total cleftlip（11.26/10 000）,hydrocephalus（8.41/10 000）,neural tube defects（6.84/10 000）,limb reduction（3.99/10 000）,and etc.There was higher frequency of birth defects in male babies（125.68/10 000） than in female babies（98.63/10 000）.Conclusion Congenital heart disease is the most important birth defect.Maternal exam should include birth defect screening.