注射用炎琥宁致53例不良反应文献分析

Literature Analysis of the Adverse Reactions in 53 Cases Induced by Potassium Sodium Dehydroandroan Drographolide Succinate for Injection

目的:探讨注射用炎琥宁致药品不良反应(ADR)的一般规律及特点,为临床合理用药提供参考。方法:检索1994年1月-2010年12月中国知网和万方数据报道的53例注射用炎琥宁ADR病例,对患者的一般情况、用药情况、ADR发生情况等进行分析。结果:注射用炎琥宁所致53例ADR病例中男性29例(54.72%),女性23例(43.40%),<10a年龄组患者ADR发生率最多,占50.94%,其出现时间多发生于用药后30min内。ADR累及多个器官系统,临床表现复杂多样,主要表现为变态反应,严重者可出现过敏性休克。结论:临床医师、药师应了解注射用炎琥宁所致ADR的规律和特点,加强其应用的监测,以减少ADR的发生。

Objective：To explore the general pattern and characteristics of adverse drug reactions（ADRs） induced by potassium sodium dehydroandroan drographolide succinate for injection so as to provide references for clinical rational drug use.Methods：The above-mentioned case reports published in China National Knowledge Infrastructure（CNKI）and Wanfang Datas from Jan.1994 to Dec.2010 were collected.The patients＇ baseline characteristics,the situation of drug use and clinical features of ADRs were analyzed.A statistical analysis was conducted on 53 ADR cases induced by potassium sodium dehydroandroan drographolide succinate for injection.Results：Among the ADR cases,29 cases（54.72%） were male and 23 cases（43.40%） were female,50.94% occurred in the age group of less than ten years.They usually occurred within 30 minutes after taking the drug.ADRs could involve in multiple organs and systems.The clinical manifestations were various and mainly were allergic reactions.Severe allergic reactions could result in anaphylactic shock.Conclusion：Doctors and pharmacists should well know the pattern and characteristics of ADRs,and the use of the drug should be under the strict monitoring to reduce the occurrence of serious ADR.