血管内皮生长因子-C在卵巢上皮癌血清中的表达及其与侵袭和淋巴结转移的关系

The relationship of the expression and lymph node metastasis of serum vascular endothelial growth factor-C in epithelial ovarian carcinoma

目的观察血管内皮生长因子-C(VEGF-C)在卵巢上皮癌患者血清中的表达及其与侵袭、淋巴结转移的关系。方法 52例卵巢上皮癌患者,根据术后病理分为伴淋巴结转移亚组29例,不伴淋巴结转移亚组23例;另选择卵巢囊肿手术患者11例采用酶联免疫吸附技术(ELISA法)检测上述患者血清中VEGF-C的水平,并探讨其与卵巢上皮癌的侵袭及淋巴道转移的关系。结果卵巢上皮癌组清中VEGF-C的水平明显高于卵巢囊肿组(P<0.05)。卵巢上皮癌Ⅲ～Ⅳ期患者血清VEGF-C水平明显高于Ⅰ～Ⅱ期(P<0.05);Ⅲ级亚组明显高于Ⅰ～Ⅱ级亚组(P<0.05);伴淋巴结转移亚组血清VEGF-C水平明显高于不伴淋巴结转移亚组(P<0.05)结论血清VEGF-C水平与卵巢上皮癌的侵袭程度及病理分级高低、淋巴结有无转移显著相关。

Objective To investigate the serum expression of vascular endothelial growth factor-C（VKGF-C）,and detect relationship between the invasion and lymph node metastasis in epithelial ovarian carcinoma.Methods Fifty two patients with epithelial ovarian carcinoma were divided into positive lymph node metastasis sub-group（n = 29） and negative lymph node metastasis sub-group（n =23）,according to pathology results.The other 11 patients with ovarian cyst were enrolled as control group.The level of VKGF-C was analyzed with enzyme linked immunosorbent assay（FLISA ） method.The relationship between the level of the VKGF-C and lymph node metastasis in epithelial ovarian carcinoma was analyzed.Results The serum level of VEGF-C in epithelial ovarian carcinoma was obviously higher than that of in the ovarian cyst group（P0.05 ）.TheⅢ～Ⅳstage was much higher than those of theⅠ～Ⅱstage（P0.05）,and theⅢgrade sub-group was higher than those of theⅠ～Ⅱsub-group（P0.05）.The positive lymph node metastasis sub-group was higher than that of in the negative sub-group（P0.05 ）.Conclusion The level of the serum VKGF-C was closely correlated to invasion,pathology differentiation and lymph node metastasis in epithelial ovarian carcinoma.