360例胃癌根治术患者的预后因素分析

Prognostic factors of gastric cancer patients undergoing radical resection

目的探讨胃癌根治术患者预后的影响因素。方法收集有完整随访资料的胃癌根治术患者360例．采用Kaplan-Meier生存分析、Log—rank检验单因素分析、Cox回归多因素分析及X。检验统计方法来分析影响预后的相关因素。结果单因素分析显示诸多因素与预后相关（P〈0．05）。多因素分析显示，仅年龄、术前血CEA、肿瘤浸润深度、淋巴结转移度、神经侵犯及术后辅助化疗周期数为独立预后因素（P〈0．05）。另外，p53蛋白与以上各因素及预后均无相关性。结论胃癌根治术患者的年龄、术前血CEA、肿瘤浸润深度、淋巴结转移度、神经侵犯以及术后辅助化疗是影响其生存的独立预后因素；术后辅以个体化、足量疗程的化疗是改善胃癌根治术患者预后的重要因素。

Objective To investigate the prognostic factors related to gastric cancer patients undergoing radical gastrectomy. Methods The clinical data of 360 gastric cancer patients who underwent radical gastrectomy were collected. Kaplan-Meier survival analysis, Log-rank univariate analysis, Cox regression analysis and Chi-square test were applied to analyze prognostic factors. Results In the univariate analysis, many factors were related to the prognosis of gastric cancer （P〈0.05）. Multivariate Cox model analysis showed that the age, preoperative blood CEA, depth of infiltration, lymph node metastasis and postoperative ad- juvant chemotherapy were independent prognostic factors for patients with gastric cancer receiving radical gastrectomy. Conclusion The study reveals prognostic factors of patients with gastric cancer undergoing radical gastrectomy, among which individualized and sufficient postoperative adjuvant chemotherapy is most important.