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支气管哮喘患者外周血PAI-1、u-PA、u-PAR、IgE的表达及意义 被引量：2

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摘要 支气管哮喘（简称哮喘）是由多种细胞（如嗜酸性粒细胞、肥大细胞、T淋巴细胞、中性粒细胞、气道上皮细胞）和细胞组分参与的、由免疫球蛋白E（IgE）介导的气道慢性炎症性疾病,传统观点认为哮喘的特征是气道慢性炎症,可逆性的气流受限,
作者 张秋娣 刘皓 张素娟 周倜
机构地区 常州市第一人民医院呼吸科
出处 《临床荟萃》 CAS 2011年第19期1687-1689,共3页 Clinical Focus
关键词 哮喘 纤溶酶原激活物抑制物1 尿纤溶酶原激活物 尿纤溶酶原激活物受体 免疫球蛋白E
分类号 R562.25 [医药卫生—呼吸系统]
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参考文献9

  • 1Oh CK,Ariue B, Alban RF, et al. PAI-1 promotes extracellular matrix deposition in the airways of a murine asthma model[J]. Biochem Biophys Res Commun,2002,294(5):1055-1060.
  • 2Cho SH, Hall IP,Wheatley A, et al. Possible role of the 4G/5G polymorphism of the plasminogen activator inhibitor 1 gene in the development of asthma[J]. J Allergy Clin Immunol, 2001, 108(2) :212-214.
  • 3Buckova D, Izakovicova Holla L, Vacha J. Polymorphism 4G/5G in the plasminogen activator inhibitor-1 (PAl 1 ) gene is associated With IgE-mediated allergic diseases and asthma in the Czech population[J]. Allergy, 2002,57 (5) : 446-448.
  • 4中华医学会呼吸病学分会哮喘学组.支气管哮喘防治指南(支气管哮喘的定义、诊断、治疗及教育和管理方案)[J].中华结核和呼吸杂志,2003,26(3):132-138. 被引量：3561
  • 5Vignola AM,Mirabella F, Costanzo G, et al. Airway remodeling in asthma[J]. Chest, 2003,123 (3 Suppl) :417s-422s.
  • 6Castellino FJ, Ploplis VA. Structure and function of the plasminogen/plasmin system [J]. Thromb Haemost, 2005, 93 (4) :647-654.
  • 7Waltz DA, Fujita RM, Yang X, et al. Nonproteolytic role for the urokinase receptor in cellular migration in vivo[J]. Am J Respir Cell Mol Biol,2000,22(3) :316-322.
  • 8Brooks AM, Bates ME, Vrtis RF, et al. Urokinase-type plasminogen activator modulates airway eosinophil adhesion in asthma[J]. Am J Respir Cell Mol Biol,2006,35(5) :503-511.
  • 9Gyetko MR, Sud S, Sonstein J, et al. Antigen-driven lymphocyte recruitment to the lung is diminished in the absence of urokinase-type plasminogen activator (uPA) receptor, hut is independent of uPA[J]. J Immunol,2001,167(10) : 5539-5542.

共引文献3560

同被引文献12

  • 1Gortner L, Monz D, Mildau C, et al. Bronchopulmonary dysplasia in a double-hit mouse model induced by intrauterine hypoxia and postnatal hyperoxia , Closer to clinical features [J] ? Ann Anat, 2013,195 (4) : 351-358.
  • 2Coalson 11. Pathology of new bronchopulmonary dysplasia [J]. Semin Neonatol, 2003, 8( 1): 737.
  • 3Cunha GS, Mezszagappa Filho F, Ribeiro ID. Risk factors for bronchopulmonary dysplasia in very low birth weight newborns treated with mechanical ventilation in the first week of life [J]. Trop Pediatr, 2005,51 (6) : 334-340.
  • 4Brander L, Sinderby C, Lecomte F, et al. Neurally adjusted ventilatory assist decreases ventilator induced lung injury and non-pulmonary organ dysfunction in rabbits with acute lung injury[J]. Intensive CareMed, 2009,35(11): 1979-1989.
  • 5Chess PRD, Angio CT, Pryhuber GS, et al. Pathogenesis of Bronchopulmonary Dysplasia [J]. SeminPerinatol, 2006, 30 ( 4 ) : 171-178.
  • 6Wagenaar GT, ter Horst SA, van Gastelen MA, et al. Gene expression profile and histopathology of experimental bronchopulmonary dysplasia induced by prolonged oxidative stress[J]. Free Radic Biol Med, 2004,36(6):782-801.
  • 7Ma Z, Paek D, Oh CK. Plasminogen activator inhibitor-1 and asthma: role in the pathogenesis and molecular regulation [J] . Clin Exp Allergy, 2009,39(8): 1136-1144.
  • 8刘冬云,吴静,张小英,封志纯.支气管肺发育不良新生儿支气管肺泡灌洗液IL-8 SP-A和TGF-β1的表达[J].中国当代儿科杂志,2010,12(6):444-446. 被引量：22
  • 9王玲,封志纯,吕回.血管内皮生长因子和血管生成素-1在高氧诱导新生鼠支气管肺发育不良的表达及其对肺发育的影响[J].实用医学杂志,2014,30(4):525-528. 被引量：17
  • 10Alan H.Jobe,吕勇.肺发育和肺损伤-新型支气管肺发育不良[J].中国当代儿科杂志,2001,3(4):345-347. 被引量：26

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临床荟萃
2011年 第19期

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