复方隔山消颗粒对胃肠运动的影响

Effect of compound Geshanxiao granules on gastrointestinal motility and its mechanism of action

目的:探讨复方隔山消颗粒对胃肠运动的影响及其机制。方法:用硫酸阿托品抑制小鼠小肠推进运动,观察复方隔山消颗粒对小肠推进运动的影响;以夹尾刺激法制造大鼠功能性消化不良模型,观察复方隔山消颗粒对模型大鼠胃黏膜一氧化氮(NO)含量和血中胃肠激素水平的影响。结果:复方隔山消颗粒能明显提高小肠运动受抑小鼠的小肠推进功能,显著降低功能性消化不良大鼠胃黏膜NO含量,明显升高其血清胃泌素(GAS)和血浆胃动素(MTL)含量。结论:复方隔山消颗粒能促进胃肠运动,其机制可能与其降低胃黏膜NO含量,提高血清GAS和血浆MTL水平有关。

OBJECTIVE To discuss the effect of compound Geshanxiao granules on gastrointestinal motility and its mechanism action. METHODS The effect of compound Geshanxiao granules on intestinal propulsive activity of mice was investigated by using atropine sulfate to inhibit the intestinal propulsive activity.observing the compound Geshanxiao granules the effect of compound Geshanxiao granules on the contents of model rats nitrogen oxide（NO） in gastric mucous membrane;on the level of rat blood gastrin（GAS） and motilin（MTL） was observed by using clipping tail stimulation method to produce rat functional dyspepsia model. RESULTS Compound Geshanxiao granules could apparently increase mice intestinal propulsive activity,significantly decrease the contents of NO in gastric mucous membrane,and increase the contents of GAS in serum and MTL in plasma of functional dyspepsia model rats. CONCLUSION Compound Geshanxiao granules can improve mice intestinal propulsive activity.It perhaps facilitates intestinal activity and ameliorates intestinal function by decreasing the contents of NO in gastric mucous membrane and elevating the level of rat GAS in serum and MTL in plasma.