坎地沙坦联合美托洛尔对收缩性心力衰竭的疗效及相关因素分析

Effects of candesartan in combination with small dose metoprolol in the treatment of contract heart failure and analysis on the relative factors

目的观察坎地沙坦联合小剂量美托洛尔治疗收缩性心力衰竭(CHF)的疗效和对左室舒张末期内径及左室射血分数的影响。方法 120例CHF患者随机分为试验组和对照组,各60例。对照组,应用常规药物(利尿剂、扩血管药物及洋地黄)治疗;治疗组,在对照组治疗基础上,加用坎地沙坦4 mg.d-1,1天1次和美托洛尔12.5 mg,每日2次。均服用48周,尔后观察比较2组临床疗效、左室舒张末期内径(LVEDd)及左室射血分数(LVEF)的变化。结果试验组临床总有效率明显优于对照组(P<0.05);与对照组比较,试验组LVEDd明显下降(P<0.05),LVEF明显增高(P<0.05)。结论坎地沙坦联合小剂量美托洛尔治疗CHF临床疗效明显。

Objective To study on the candesartan in combination with small dose metoprolol in the treatment of contract heart failure（CHF） and analyze the influence factors on left entricular end-diastolic diameter and left ventricular ejection fraction.Methods One hundred twenty cases of CHF patients were divided into trial group（60 cases） and control group（60 cases）.The control group used routine drugs（diuretics,enlarge the vascular drugs）.The trial group treated by 4 mg of candesartan and 12.5 mg of metoprolol for 48 weeks.Clinical curative effects,left ventricular end-diastolic diameter（LVEDd） and left ventricular ejection fraction（LVEF） changes were observed and compared in two groups.Results The total effective rate in trial group was better than in control group（P0.05）.Compared with control group,LVEDd was decreased in trial group（P0.05）,LVEF was increased in trial group（P0.05）.Conclusion Clinical efficacy of candesartan combination with small dose metoprolol is obvious for treatment CHF.