丁香酸衍生物的合成及抗血小板聚集活性

Synthesis and anti-platelet aggregation activity of syringic acid derivatives

目的:合成丁香酸衍生物并考察其抗血小板聚集活性。方法:以丁香酸乙酯为原料,经W il-liamson醚化和水解反应合成丁香酸衍生物,并通过抗血小板聚集试验对目标化合物进行抗血小板聚集活性评价。结果与结论:合成了2个目标化合物,其结构经IR,1H-NMR,13C-NMR及MS确证。初步药理实验结果表明,目标化合物在体外显示出较好的抗血小板聚集活性。

Objective： To synthesize syringic acid derivatives and evaluate their anti-platelet aggregation activity. Methods： Syringic acid derivatives were synthesized from ethyl syringate via Williamson etherifation and hydroxylation. The target compounds were assayed for anti-platelet aggregation activity in vitro. Results and conclusion： Two compounds were synthesized. Their structures were confirmed by IR, ^1H-NMR, 13C-NMR and MS. Preliminary pharmacological results showed that the tested compounds exhibited potential anti-platelet aggregation activity.